2. Immunology/Inflammation Apoptosis Autophagy
  3. PD-1/PD-L1 Apoptosis Autophagy
  4. Atezolizumab

Atezolizumab  (Synonyms: 阿特珠单抗; MPDL3280A)

目录号: HY-P9904 纯度: 99.50%
COA

摩尔计算器

Atezolizumab (MPDL3280A) 是一种人源化单克隆抗体 IgG1，抵抗程序性死亡因子配体1 (PD-L1)，用于癌症研究。

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CAS No. : 1380723-44-3

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规格 价格 是否有货 数量
1 mg ￥1900
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5 mg ￥5300
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10 mg ￥8215
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50 mg   询价  
100 mg   询价  

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Customer Review

Atezolizumab 相关抗体

Top Publications Citing Use of Products

    Atezolizumab purchased from MCE. Usage Cited in: EJNMMI Res. 2020 Jun 15;10(1):64.  [Abstract]

    Western blot analysis of total cell lysates using anti-PD-L1 (Atezolizumab, 6.91 nM) and anti-β-actin antibody between LoVo, LS174T, SW620, and RKO in vitro.

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

    同型

    Human IgG1 kappa
    推荐同型对照抗体
    种属

    Humanized
    体外研究
    (In Vitro)

    Atezolizumab（0、2.5、5、10、20 和 40 μg/mL；24 小时；HOS 和 143B 细胞）可抑制骨肉瘤细胞增殖并诱导免疫非依赖性凋亡[1]。
    Atezolizumab 通过破坏线粒体功能，导致氧化剂和抗氧化剂之间的失衡。Atezolizumab 通过激活 JNK 通路诱导骨肉瘤细胞线粒体相关凋亡[1]。
    Atezolizumab（10 μg/mL；24 小时；HOS 和 143B 细胞）诱导骨肉瘤细胞自噬[1]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Atezolizumab 相关抗体:
    Clinical Trial
    CAS 号
    性状

    液体

    颜色

    Colorless to light yellow

    中文名称

    阿特珠单抗；阿替利珠单抗
    运输条件

    Shipping with dry ice.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Flow cytometry analysis of PD-L1 overexpression HEK293 cells labelling PD-L1 with Atezolizumab at 67nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
    纯度 & 产品资料

    纯度: 99.50%

    COA (264 KB) SDS-PAGE (93 KB) SEC-HPLC (122 KB)

    抗体抑制剂使用指南 (1152 KB)
    参考文献

    Atezolizumab 相关分类

    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Atezolizumab1380723-44-3MPDL3280A阿特珠单抗阿替利珠单抗PD-1/PD-L1ApoptosisAutophagyPD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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