Bactenecin (Synonyms: 抗菌肽; Bactenecin, bovine)

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Bactenecin (Bactenecin, bovine) 是一种从牛嗜中性粒细胞中分离出来的有效的含 12 个氨基酸的环状抗菌肽。Bactenecin 抑制细菌和酵母菌 (bacteria 和 yeast) 的生长，并能杀死真菌红毛癣菌 (fungus Trichophyton rubrum)。Bactenecin 增加了膜的通透性，抑制了假苹果芽孢杆菌 (B. pseudomallei) 的生长和生物膜的形成。

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Bactenecin Chemical Structure

CAS No. : 116229-36-8

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生物活性
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参考文献

生物活性	Bactenecin (Bactenecin, bovine) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin increass membrane permeability, inhibits the growth and biofilm formation of *B. pseudomallei*^[1]^[2]^[3].
IC₅₀ & Target	Bacteria; Yeast; Fungus^[1]
体外研究 (In Vitro)	Bactenecin is synthesized by solid-phase peptide synthesis and renatured to a fully disulfide bonded form. Bactenecin inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration reported for the peptide purified from bovine neutrophils. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus Trichophyton rubrum^[1]. Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells^[2]. Bactenecin exhibits stronger binding to LPS and induces perturbation of the inner membrane of live cells. Interaction of Bactenecin with model membranes results in changes in membrane fluidity and permeability, leading to leakage of dye across the membrane^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Bactenecin 相关抗体:
分子量	1483.89
Formula	C₆₃H₁₁₈N₂₄O₁₃S₂
CAS 号	116229-36-8
Sequence	Arg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg (Disulfide bridge: Cys3-Cys11)
Sequence Shortening	RLCRIVVIRVCR (Disulfide bridge: Cys3-Cys11)
中文名称	抗菌肽
结构分类	Antibiotics Disease Research Antibacterial Antibiotics Other Antibiotics
初始来源	动物 bovine neutrophils
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料	Data Sheet (537 KB) 产品使用指南 (1538 KB)
参考文献	[1]. Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1(4):335-46. [Content Brief] [2]. Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36(6):657-62. [Content Brief] [3]. Kanjana Madhongsa, et al. Antimicrobial Action of the Cyclic Peptide Bactenecin on Burkholderia Pseudomallei Correlates With Efficient Membrane Permeabilization. PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2267. [Content Brief]

Cell Assay ^[2]	Rat neuronal cells (5000 cells/well) are incubated for 24 hr with bactenecin (0.3, 0.6, 1.25, 2.5, 5, 10, 20, 40 μg/mL) or the control peptide. Cytotoxicity is assayed in 96-well tissue culture plates using a commercially available kit. The method is based on cellular reduction of tetrazolium salt into intensely coloured formazan derivates.^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1(4):335-46. [Content Brief] [2]. Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36(6):657-62. [Content Brief] [3]. Kanjana Madhongsa, et al. Antimicrobial Action of the Cyclic Peptide Bactenecin on Burkholderia Pseudomallei Correlates With Efficient Membrane Permeabilization. PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2267. [Content Brief]

Cell Assay
^[2]

Rat neuronal cells (5000 cells/well) are incubated for 24 hr with bactenecin (0.3, 0.6, 1.25, 2.5, 5, 10, 20, 40 μg/mL) or the control peptide. Cytotoxicity is assayed in 96-well tissue culture plates using a commercially available kit. The method is based on cellular reduction of tetrazolium salt into intensely coloured formazan derivates.^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1(4):335-46. [Content Brief]

[2]. Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36(6):657-62. [Content Brief]

[3]. Kanjana Madhongsa, et al. Antimicrobial Action of the Cyclic Peptide Bactenecin on Burkholderia Pseudomallei Correlates With Efficient Membrane Permeabilization. PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2267. [Content Brief]

Bactenecin 相关分类

Infection

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Bactenecin (Synonyms: 抗菌肽; Bactenecin, bovine)

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Bactenecin (Synonyms: 抗菌肽; Bactenecin, bovine)

Customer Review

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Bactenecin 相关抗体

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