2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Bometolol Hydrochloride

Bometolol Hydrochloride  (Synonyms: 波美洛尔盐酸盐)

目录号: HY-U00386
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摩尔计算器

Bometolol Hydrochloride 是一种 beta-adrenergic 阻滞剂，可用于高血压等心血管疾病的研究。

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Bometolol Hydrochloride Chemical Structure

Bometolol Hydrochloride Chemical Structure

CAS No. : 65023-16-7

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Bometolol Hydrochloride 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bometolol Hydrochloride is a beta-adrenergic blocking agent, used for the research of cardiovascular disease.

IC50 & Target

Beta-adrenergic receptor[1]
体内研究
(In Vivo)

Bometolol (10-30 mg/kg, p.o.) lowers the blood pressure dose-dependently in spontaneously hypertensive rats, deoxycorticosterone and salt hypertensive rats and two kindey, one clip hypertensive rats. In subchronic study, Bometolol (10-30 mg/kg, or 100-300 mg/kg, p.o.) dose-dependently decreases heart rate, plasma renin activity, heart and kindey weitht and incidence of vascular lesion, but shows no antihypertensive effects in all the hypertensive rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

508.99

Formula

C25H33ClN2O7
CAS 号
中文名称

波美洛尔盐酸盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Rats[1]
In the acute experments, normal female Donryu strain (DON, 14-15 weeks, 250-270 g), and SHR (17-18 weeks, 180-200 g), DOC (7-9 weeks, 180-210 g), and CLIP (7-9 weeks, 180-210 g) hypertensive rats are used. Bometolol hydrochloride is dissolved in H2O and 0.01% Tween 80 solution at a volume of 5 mL/kg body weight for the acute and subchronic studies, respectively. The doses are in terms of the free base. The solution is administratered orally by a gastric tube. In the acute experiment, H2O (5 mL/kg) is giver to the control groups. In the subchronic experment, the drug is administered once a day for 5 weeks, 5 days per week, and Tween 80 solution (5 mL/kg) is given to the control groups[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Bometolol Hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bometolol65023-16-7波美洛尔盐酸盐Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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