Clocapramine  (Synonyms: 氯卡帕明; Clocarpramine; 3-Chlorocarpipramine)

Clocapramine is an antagonist of the D₂, 5-HT_2A receptors.

Clocapramine has a moderate affinity for D₂-receptors in vitro. Clocapramine shows higher affinity for 5-HT_2A than for D₂-receptors in vitro^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clocapramine shows the lowest potency for D₂-occupancy in vivo^[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D₂ and frontal serotonin-5-HT₂ receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT₂ versus D₂ receptors that fall between these two groups (ED₅₀ of 14.5 mg/kg for D₂, 4.9 mg/kg for 5-HT₂)^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

481.07

C₂₈H₃₇ClN₄O

47739-98-0

氯卡帕明；氯卡比咪嗓；罗卡普胺

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69(4):399-412.  [Content Brief]

  [2]. Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64.  [Content Brief]