2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Clocapramine dihydrochloride hydrate

Clocapramine dihydrochloride hydrate  (Synonyms: 3-Chlorocarpipramine dihydrochloride hydrate)

目录号: HY-B2073A
产品使用指南

摩尔计算器

Clocapramine hydrochloride hydrate 是多巴胺 D2 和 5-HT2A 受体拮抗剂。

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Clocapramine dihydrochloride hydrate Chemical Structure

Clocapramine dihydrochloride hydrate Chemical Structure

CAS No. : 60789-62-0

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Other Forms of Clocapramine dihydrochloride hydrate:

Clocapramine dihydrochloride hydrate 相关抗体

Top Publications Citing Use of Products

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors.

IC50 & Target

D2 Receptor

 

5-HT2A Receptor

 

体内研究
(In Vivo)

Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

572.01

Formula

C28H41Cl3N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[2]

Rats[2]
Male Wistar rats (210 to 240 g) are housed in a temperature-controlled room with a 12-hour dark/light cycle (lights on at 8:30) and have free access to food and water. For competition studies, rats are pretreated with an intraperitoneal injection of varying doses of antipsychotic drugs or the same volume (0.21 to 0.24 mL) of the corresponding vehicle (DMSO), 10 minutes prior to the injection of [3H]-YM-09151-2 or [3H]-ketanserin[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Clocapramine dihydrochloride hydrate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clocapramine dihydrochloride60789-62-03-Chlorocarpipramine dihydrochloride5-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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