2. Epigenetics
  3. Histone Demethylase
  4. DDP-38003 dihydrochloride

DDP-38003 dihydrochloride 

目录号: HY-19612A 纯度: 98.22%
COA 产品使用指南

摩尔计算器

DDP-38003 dihydrochloride 是具有口服活性的KDM1A/LSD1抑制剂，IC50 值为 84 nM。

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DDP-38003 dihydrochloride Chemical Structure

DDP-38003 dihydrochloride Chemical Structure

CAS No. : 1831167-98-6

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规格 价格 是否有货 数量
1 mg ￥900
In-stock
5 mg ￥1700
In-stock
10 mg ￥2900
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of DDP-38003 dihydrochloride:

DDP-38003 dihydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Histone Demethylase 亚型特异性产品:

查看所有亚型
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM[1].

IC50 & Target

KDM1/LSD1

 

体外研究
(In Vitro)

DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DDP-38003 dihydrochloride 相关抗体:
体内研究
(In Vivo)

DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

423.38

Formula

C21H28Cl2N4O
CAS 号
性状

固体

颜色

Brown to reddish brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 29 mg/mL (68.50 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3619 mL 11.8097 mL 23.6194 mL
5 mM 0.4724 mL 2.3619 mL 4.7239 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.22%

COA (191 KB) RP-HPLC (206 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

Mice: CD-1 mice is used in the study. DDP-38003 is dissolved (40% PEG 400 in a 5% glucose solution) and orally administered 3 days per week (Monday, Tuesday and Wednesday) for 3 weeks at the doses of 11.25 mg/kg and 22.5 mg/kg. The treatment started once blast cells are detected in the recipients' peripheral blood (10 days after cell injection). The survival of mice of the different experimental groups is analyzed and represented by a Kaplan-Meier survival plot[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

DDP-38003 dihydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3619 mL 11.8097 mL 23.6194 mL 59.0486 mL
5 mM 0.4724 mL 2.3619 mL 4.7239 mL 11.8097 mL
10 mM 0.2362 mL 1.1810 mL 2.3619 mL 5.9049 mL
15 mM 0.1575 mL 0.7873 mL 1.5746 mL 3.9366 mL
20 mM 0.1181 mL 0.5905 mL 1.1810 mL 2.9524 mL
25 mM 0.0945 mL 0.4724 mL 0.9448 mL 2.3619 mL
30 mM 0.0787 mL 0.3937 mL 0.7873 mL 1.9683 mL
40 mM 0.0590 mL 0.2952 mL 0.5905 mL 1.4762 mL
50 mM 0.0472 mL 0.2362 mL 0.4724 mL 1.1810 mL
60 mM 0.0394 mL 0.1968 mL 0.3937 mL 0.9841 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDP-380031831167-98-6DDP38003DDP 38003Histone DemethylaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
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