FTY720 (S)-Phosphate (Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)

目录号: HY-15382 纯度: 99.73% ee.: 99.76%: FAQs
Data Sheet SDS COA 产品使用指南

摩尔计算器

FTY720 (S)-Phosphate 是一种 S1P 受体 1 (S1PR1) 激动剂，可以用于急性肺损伤等急性炎症的研究。

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FTY720 (S)-Phosphate Chemical Structure

CAS No. : 402616-26-6

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规格	价格	是否有货
1 mg	￥2080	In-stock
5 mg	￥5200	In-stock
10 mg	现货	询价
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100 mg		询价

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Customer Review

Other Forms of FTY720 (S)-Phosphate:

Fingolimod phosphate In-stock
(S)-FTY720-phosphonate In-stock

MCE 顾客使用本产品发表的 1 篇科研文献

•Front Immunol. 2017 Oct 19;8:1345. [Abstract]

FTY720 (S)-Phosphate 相关产品

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

FTY720 (S)-Phosphate is an agonist of S1P receptor 1 (S1PR1), used in the research of acute inflammatory diseases such as acute lung injury.

IC₅₀ & Target

S1PR1^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
CHO	EC₅₀	> 10000 nM Compound: (S)-5	Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-2 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	0.28 nM Compound: 2	Induction of internalization of C-terminal GFP-fused human S1P1 receptor expressed in CHO cell membranes after 50 mins Induction of internalization of C-terminal GFP-fused human S1P1 receptor expressed in CHO cell membranes after 50 mins	[PMID: 26924461]
CHO	EC₅₀	0.3 nM Compound: (S)-5	Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-1 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	0.3 nM Compound: (S)-5	Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-5 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	EC₅₀	0.6 nM Compound: (S)-5	Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-4 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	IC₅₀	2.1 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P1 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO	IC₅₀	2.2 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P4 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO	IC₅₀	23 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P3 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P3 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO	EC₅₀	3.1 nM Compound: (S)-5	Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand Agonism of human S1P-3 receptor expressed in CHO cells, 90-120 min in pH 7.4 using [35S]GTP-gamma-S as radioligand	[PMID: 16078855]
CHO	IC₅₀	5.9 nM Compound: (S)-FTY720-P, (S)-FTY720-Phosphate	Agonist activity at human S1P2 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay Agonist activity at human S1P2 expressed in CHO cells after 60 mins by [35S]GTPgammaS binding assay	[PMID: 22119341]
CHO-K1	EC₅₀	0.027 μM Compound: 2a, FTY720-P	Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay Agonist activity at human S1P3 receptor expressed in CHO-K1 cells co-expressing Gq/i5 G-protein assessed as calcium mobilization by FLIPR assay	[PMID: 22104144]
CHO-K1	EC₅₀	0.29 nM Compound: 2, FTY720-P	Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at rat S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	0.37 nM Compound: 2, FTY720-P	Agonist activity at human S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at human S1P1 receptor expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	1.3 nM Compound: 2, FTY720-P	Agonist activity at rat S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at rat S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	2 nM Compound: 1-P	Agonist activity at human S1P3 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay Agonist activity at human S1P3 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay	[PMID: 24909680]
CHO-K1	EC₅₀	3.3 nM Compound: 2, FTY720-P	Agonist activity at human S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay Agonist activity at human S1P3R expressed in CHO-K1 cells by [35S]GTPgammaS binding assay	[PMID: 24900318]
CHO-K1	EC₅₀	7 nM Compound: 1-P	Agonist activity at human S1P1 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay Agonist activity at human S1P1 receptor expressed in CHOK1 cell membranes by [35S]GTPgammaS binding assay	[PMID: 24909680]
U2OS	EC₅₀	0.4 nM Compound: FTY720P	Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay Agonist activity at human S1P1 receptor expressed in EDG1-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay	[PMID: 26687487]
U2OS	EC₅₀	94 nM Compound: FTY720P	Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay Agonist activity at human S1P3 receptor expressed in EDG3-bla U2OS cells incubated for 18 hrs prior to GenBlazer substrate addition by beta-arrestin recruitment assay	[PMID: 26687487]

体外研究
(In Vitro)

FTY720 (S)-Phosphate 是 S1PR1 的激动剂。FTY720 (S)-Phosphate (Tys，1 μM) 维持 S1PR1 蛋白表达，通过 S1PR1 增强人肺动脉内皮细胞屏障，但对诱导 S1PR1 泛素化没有影响。FTY720 (S)-Phosphate (0.01-50 μM) 还可减少 β-arrestin 向 S1PR1 的募集^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

FTY720 (S)-Phosphate (0.5 mg/kg，i.p.) 保留小鼠肺中的 S1PR1 表达，对博来霉素诱导的急性肺损伤 (ALI) 具有保护作用，并减弱博来霉素损伤小鼠的肺组织白细胞浸润^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

387.45

Formula

C₁₉H₃₄NO₅P

CAS 号

402616-26-6

性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

细胞实验：

DMSO 中的溶解度 : 1 mg/mL (2.58 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H₂O 中的溶解度 : < 0.1 mg/mL (insoluble)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5810 mL	12.9049 mL	25.8098 mL
5 mM	---	---	---
10 mM	---	---	---

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物实验：

以下溶解方案源自文献，仅供参考，建议您先取少量样品进行尝试。

方案一

FTY720 (S)-Phosphate is dissolved in sterile water^[2].

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 99.73% ee.: 99.76%

选择批次：

Data Sheet (610 KB) SDS (252 KB)

COA (285 KB) HNMR (204 KB) RP-HPLC (260 KB) NP-HPLC (455 KB) LCMS (95 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Wang L, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42(3):e189-99. [Content Brief]

[2]. Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. [Content Brief]

Animal Administration ^[1]	Mice^[1] Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Wang L, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42(3):e189-99. [Content Brief] [2]. Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. [Content Brief]

Animal Administration
^[1]

Mice^[1] Male C57BL/6 (20-25 g) mice 8-10 weeks old receive a single intratracheal dose of bleomycin at 0.6 U/kg (or sterile saline) on Day 0 followed immediately by intraperitoneal injection of FTY720 (S)-Phosphate (0.5 mg/kg), FTY720 (0.5 mg/kg), or saline. Additional doses of FTY720 (S)-Phosphate or FTY720 are injected on Days 3 and 6. Bronchoalveolar lavage (BAL) fluid and lungs are then collected on Day 7. BAL fluid is used to detect BAL protein levels, WBC count, and WBC differential count. Lungs are perfused with saline to remove blood for Western blot, tissue albumin, and histopathology evaluation. Peripheral blood is obtained on Day 7 for examination of total cell counts and lymphocytes. Experiments are repeated 3 times. 6-10 mice are used per experimental group^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Wang L, et al. FTY720 (s)-phosphonate preserves sphingosine 1-phosphate receptor 1 expression and exhibits superior barrier protection to FTY720 in acute lung injury. Crit Care Med. 2014 Mar;42(3):e189-99. [Content Brief]

[2]. Lingling Jia, et al. Clostridium butyricum CGMCC0313.1 Protects against Autoimmune Diabetes by Modulating Intestinal Immune Homeostasis and Inducing Pancreatic Regulatory T Cells. Front Immunol. 2017 Oct 19;8:1345. [Content Brief]

FTY720 (S)-Phosphate 相关分类

Inflammation/Immunology

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO

1 mM

2.5810 mL

12.9049 mL

25.8098 mL

64.5245 mL

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTY720 (S)-Phosphate402616-26-6(S)-FTY720P(S)-FTY720LPL ReceptorLysophospholipid ReceptorInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FTY720 (S)-Phosphate (Synonyms: (S)-FTY720P; (S)-FTY720 phosphate)

Customer Review

Other Forms of FTY720 (S)-Phosphate:

MCE 顾客使用本产品发表的 1 篇科研文献