2. Autophagy
  3. Autophagy
  4. Licochalcone A

Licochalcone A  (Synonyms: 甘草查尔酮A; Licochalcone-A)

目录号: HY-N0372 纯度: 99.89%
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甘草查尔酮A (Licochalcone A) 是一种黄酮类化合物，具有抗癌功效，对UDP-glucuronosyltransferases (UGTs) 具有广泛抑制活性。Licochalcone A (LCA) 对 UGT1A1、1A3、1A4、1A6、1A7、1A9 和 2B7 具有强烈的抑制作用 (IC50 和Ki值均低于5 μM)。

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Licochalcone A Chemical Structure

Licochalcone A Chemical Structure

CAS No. : 58749-22-7

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Other Forms of Licochalcone A:

Licochalcone A 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs)[1]. Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) [2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO-K1 IC50
508.3 μM
Compound: 118
Cytotoxicity against CHO-K1 cells incubated for 24 hrs by colorimetric assay
Cytotoxicity against CHO-K1 cells incubated for 24 hrs by colorimetric assay
[PMID: 33479649]
HEK293 IC50
0.28 nM
Compound: Licochalcone A
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
[PMID: 32347726]
HEK293 IC50
0.3 nM
Compound: Licochalcone A
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
[PMID: 32347726]
HEK293 IC50
0.3 nM
Compound: Licochalcone A
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
[PMID: 32347726]
HEK293 IC50
0.31 nM
Compound: Licochalcone A
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
Effect on etoposide-induced cytotoxicity against HEK293 cells by measuring etoposide IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb =0.21 +/- 0.04 uM)
[PMID: 32347726]
HEK293 IC50
10 μM
Compound: Licochalcone A
Cytotoxicity against HEK293 cells after 72 hrs by CCK8 assay
Cytotoxicity against HEK293 cells after 72 hrs by CCK8 assay
[PMID: 32347726]
HEK293 IC50
10 μM
Compound: Licochalcone A
Cytotoxicity against HEK293 cells overexpressing human ABCG2 after 72 hrs by CCK8 assay
Cytotoxicity against HEK293 cells overexpressing human ABCG2 after 72 hrs by CCK8 assay
[PMID: 32347726]
HEK293 IC50
24.72 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
[PMID: 32347726]
HEK293 IC50
25.55 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
[PMID: 32347726]
HEK293 IC50
25.89 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
[PMID: 32347726]
HEK293 IC50
26.83 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
Effect on topotecan-induced cytotoxicity against HEK293 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 24.60 +/- 5.98 nM)
[PMID: 32347726]
HEK293 IC50
4.6 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
[PMID: 32347726]
HEK293 IC50
4.74 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
[PMID: 32347726]
HEK293 IC50
4.78 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
[PMID: 32347726]
HEK293 IC50
5.11 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
Effect on mitoxantrone-induced cytotoxicity against HEK293 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 4.70 +/- 0.99 nM)
[PMID: 32347726]
HEK293 IC50
7.99 nM
Compound: Licochalcone A
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
[PMID: 32347726]
HEK293 IC50
8.67 nM
Compound: Licochalcone A
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 0.5 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
[PMID: 32347726]
HEK293 IC50
8.9 nM
Compound: Licochalcone A
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
[PMID: 32347726]
HEK293 IC50
9.03 nM
Compound: Licochalcone A
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
Effect on Colchicine-induced cytotoxicity against HEK293 cells by measuring colchicine IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 8.42 +/- 3 nM)
[PMID: 32347726]
HEK-293T IC50
4.2 μg/mL
Compound: 2
Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
Inhibition of oseltamivir-resistant H1N1 swine influenza virus neuraminidase H274Y mutant activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
[PMID: 21123068]
HEK-293T IC50
5.42 μg/mL
Compound: 2
Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
Inhibition of wild type H1N1 swine influenza virus neuraminidase activity expressed in HEK293T cells after 2 hrs by spectrofluorometry
[PMID: 21123068]
HeLa IC50
48.5 μM
Compound: 4
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 31539776]
Hepatocyte IC50
0.927 nM
Compound: Licochalcone A
Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
[PMID: 18212104]
HK-2 IC50
88.7 μM
Compound: 4
Cytotoxicity against human HK2 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
Cytotoxicity against human HK2 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
[PMID: 31539776]
HT-1080 IC50
10.75 μM
Compound: Licochalcone A
Antiproliferative activity against human HT1080 cells harboring IDH1-R132C mutation incubated for 48 hrs
Antiproliferative activity against human HT1080 cells harboring IDH1-R132C mutation incubated for 48 hrs
[PMID: 31836442]
MCF7 IC50
22 μM
Compound: 4
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
[PMID: 31539776]
MDA-MB-231 IC50
22 μM
Compound: 4
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
[PMID: 31539776]
MSTO-211H IC50
26 μM
Compound: 4
Cytotoxicity against human MSTO-211H cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
Cytotoxicity against human MSTO-211H cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
[PMID: 31539776]
NCI-H28 IC50
30 μM
Compound: 4
Cytotoxicity against human NCI-H28 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
Cytotoxicity against human NCI-H28 cells assessed as reduction in cell viability after 24 to 48 hrs by MTS assay
[PMID: 31539776]
NCI-H460 IC50
10 μM
Compound: Licochalcone A
Cytotoxicity against human H460 cells after 72 hrs by MTT assay
Cytotoxicity against human H460 cells after 72 hrs by MTT assay
[PMID: 32347726]
NCI-H460 IC50
19.84 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
[PMID: 32347726]
NCI-H460 IC50
20.1 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
[PMID: 32347726]
NCI-H460 IC50
20.34 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
[PMID: 32347726]
NCI-H460 IC50
21.69 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
[PMID: 32347726]
NCI-H460 IC50
22.41 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
[PMID: 32347726]
NCI-H460 IC50
22.52 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
[PMID: 32347726]
NCI-H460 IC50
25.54 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
Effect on topotecan-induced cytotoxicity against human H460 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 37.42 +/- 5.45 nM)
[PMID: 32347726]
NCI-H460 IC50
25.91 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
Effect on mitoxantrone-induced cytotoxicity against human H460 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 21.61 +/- 5.85 nM)
[PMID: 32347726]
S1 IC50
10 μM
Compound: Licochalcone A
Cytotoxicity against human S1 cells after 72 hrs by MTT assay
Cytotoxicity against human S1 cells after 72 hrs by MTT assay
[PMID: 32347726]
S1 IC50
10.7 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
[PMID: 32347726]
S1 IC50
11.01 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
[PMID: 32347726]
S1 IC50
11.74 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 9.21 +/- 1.45 nM)
[PMID: 32347726]
S1 IC50
4.44 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 4.83 +/- 0.83 nM)
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 4.83 +/- 0.83 nM)
[PMID: 32347726]
S1 IC50
4.53 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 1 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
[PMID: 32347726]
S1 IC50
4.55 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 2 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
[PMID: 32347726]
S1 IC50
4.73 nM
Compound: Licochalcone A
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
Effect on mitoxantrone-induced cytotoxicity against human S1 cells by measuring mitoxantrone IC50 at 3 uM after 72 hrs by CCK8 assay (Rvb = 4.83 +/- 0.83 nM)
[PMID: 32347726]
S1 IC50
9.73 nM
Compound: Licochalcone A
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 9.21 +/- 1.45 nM)
Effect on topotecan-induced cytotoxicity against human S1 cells by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 9.21 +/- 1.45 nM)
[PMID: 32347726]
S1-M1-80 IC50
0.31 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
[PMID: 32347726]
S1-M1-80 IC50
0.41 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
[PMID: 32347726]
S1-M1-80 IC50
0.61 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
[PMID: 32347726]
S1-M1-80 IC50
1.03 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on topotecan-induced cytotoxicity by measuring topotecan IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 10.14 +/- 2.820 uM)
[PMID: 32347726]
S1-M1-80 IC50
1.53 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 3 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
[PMID: 32347726]
S1-M1-80 IC50
10 μM
Compound: Licochalcone A
Cytotoxicity against human S1-M1-80 cells harboring ABCG2 (unknown origin) after 72 hrs by MTT assay
Cytotoxicity against human S1-M1-80 cells harboring ABCG2 (unknown origin) after 72 hrs by MTT assay
[PMID: 32347726]
S1-M1-80 IC50
2.63 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 2 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
[PMID: 32347726]
S1-M1-80 IC50
39.47 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 0.5 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
[PMID: 32347726]
S1-M1-80 IC50
6.8 μM
Compound: Licochalcone A
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
Reversal of ABCG2 (unknown origin)-mediated multidrug resistance in human S1-M1-80 cells assessed as effect on mitoxantrone-induced cytotoxicity by measuring mitoxantrone IC50 at 1 uM after 72 hrs by MTT assay (Rvb = 73.62 +/- 7.20 uM)
[PMID: 32347726]
SiHa IC50
42.2 μM
Compound: 4
Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human SiHa cells assessed as reduction in cell viability after 24 hrs by MTT assay
[PMID: 31539776]
U-87MG ATCC IC50
> 50 μM
Compound: Licochalcone A
Cytotoxicity against human U87MG cells harboring wild type IDH1 incubated for 48 hrs
Cytotoxicity against human U87MG cells harboring wild type IDH1 incubated for 48 hrs
[PMID: 31836442]
WI-38 IC50
90.2 μM
Compound: 4
Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
Cytotoxicity against human WI38 cells assessed as reduction in cell viability after 24 to 48 hrs by MTT assay
[PMID: 31539776]
体外研究
(In Vitro)

Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) [2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Licochalcone A 相关抗体:
Clinical Trial
分子量

338.40

Formula

C21H22O4
CAS 号
性状

固体

颜色

Yellow to orange

中文名称

甘草查而酮 A；甘草查耳酮甲
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (369.39 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9551 mL 14.7754 mL 29.5508 mL
5 mM 0.5910 mL 2.9551 mL 5.9102 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.39 mM); 澄清溶液

    此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

    以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

  • 方案 二

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: 2.08 mg/mL (6.15 mM); 悬浊液; 超声助溶

    此方案可获得 2.08 mg/mL的均匀悬浊液，悬浊液可用于口服和腹腔注射。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。
您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料

纯度: 99.89%

COA (190 KB) HNMR (270 KB) LCMS (264 KB)

产品使用指南 (1538 KB)
参考文献

Licochalcone A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9551 mL 14.7754 mL 29.5508 mL 73.8771 mL
5 mM 0.5910 mL 2.9551 mL 5.9102 mL 14.7754 mL
10 mM 0.2955 mL 1.4775 mL 2.9551 mL 7.3877 mL
15 mM 0.1970 mL 0.9850 mL 1.9701 mL 4.9251 mL
20 mM 0.1478 mL 0.7388 mL 1.4775 mL 3.6939 mL
25 mM 0.1182 mL 0.5910 mL 1.1820 mL 2.9551 mL
30 mM 0.0985 mL 0.4925 mL 0.9850 mL 2.4626 mL
40 mM 0.0739 mL 0.3694 mL 0.7388 mL 1.8469 mL
50 mM 0.0591 mL 0.2955 mL 0.5910 mL 1.4775 mL
60 mM 0.0493 mL 0.2463 mL 0.4925 mL 1.2313 mL
80 mM 0.0369 mL 0.1847 mL 0.3694 mL 0.9235 mL
100 mM 0.0296 mL 0.1478 mL 0.2955 mL 0.7388 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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