2. Epigenetics
  3. Histone Methyltransferase
  4. MM-589

MM-589 是 WD 重复结构域 5 (WDR5) 和混合谱系白血病 (MLL) 蛋白-蛋白相互作用的有效抑制剂。 MM-589 结合 WDR5 的 IC50 为 0.90 nM。抑制 MLL H3K4 甲基转移酶活性的 IC50 为 12.7 nM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 MM-589 TFA 通常具有更好的水溶性和稳定性。

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MM-589 Chemical Structure

MM-589 Chemical Structure

CAS No. : 2097887-20-0

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规格 是否有货
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100 mg   询价  
250 mg   询价  

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MM-589 的其他形式现货产品:

Customer Review

Other Forms of MM-589:

MM-589 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

IC50 & Target

IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]

Ki: <1 nM (WDR5)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
MV4-11 IC50
250 nM
Compound: MM-589
Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay
[PMID: 35436124]
体外研究
(In Vitro)

MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MM-589 相关抗体:

Cell Viability Assay[1]

Cell Line: MV4-11 and MOLM-13 cells
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 4 days or 7 days
Result: Potently inhibited MV4-11 and MOLM-13 cell growth with IC50s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC50 of 8.6 μM.
分子量

572.70

Formula

C28H44N8O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 100 mg/mL (174.61 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7461 mL 8.7306 mL 17.4611 mL
5 mM 0.3492 mL 1.7461 mL 3.4922 mL
查看完整储备液配制表

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

MM-589 相关分类

完整储备液配制表

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7461 mL 8.7306 mL 17.4611 mL 43.6529 mL
5 mM 0.3492 mL 1.7461 mL 3.4922 mL 8.7306 mL
10 mM 0.1746 mL 0.8731 mL 1.7461 mL 4.3653 mL
15 mM 0.1164 mL 0.5820 mL 1.1641 mL 2.9102 mL
20 mM 0.0873 mL 0.4365 mL 0.8731 mL 2.1826 mL
25 mM 0.0698 mL 0.3492 mL 0.6984 mL 1.7461 mL
30 mM 0.0582 mL 0.2910 mL 0.5820 mL 1.4551 mL
40 mM 0.0437 mL 0.2183 mL 0.4365 mL 1.0913 mL
50 mM 0.0349 mL 0.1746 mL 0.3492 mL 0.8731 mL
60 mM 0.0291 mL 0.1455 mL 0.2910 mL 0.7275 mL
80 mM 0.0218 mL 0.1091 mL 0.2183 mL 0.5457 mL
100 mM 0.0175 mL 0.0873 mL 0.1746 mL 0.4365 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM-5892097887-20-0MM589MM 589Histone MethyltransferaseInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-100869
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