2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Cytochrome P450 Antibiotic
  4. Oxiconazole

Oxiconazole  (Synonyms: 奥昔康唑; Ro 13-8996 free base)

目录号: HY-B1324A
产品使用指南

摩尔计算器

Oxiconazole (Ro 13-8996) 是一种广谱抗真菌剂，能抑制念珠菌 (Candida)、曲霉属真菌 (Aspergillus) 和毛癣菌属真菌 (Trichophyton) 的生长。Oxiconazole 也是一种高效的 CYP3A4 反式激活剂，可与利福平 (Rifampicin; HY-B0272) 竞争性拮抗。Oxiconazole 通过过氧化物酶 2 (PRDX2) 介导的细胞自噬 (autophagy) 停滞来发挥抗结直肠癌的作用。

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Oxiconazole Chemical Structure

Oxiconazole Chemical Structure

CAS No. : 64211-45-6

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Oxiconazole 的其他形式现货产品:

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Other Forms of Oxiconazole:

Oxiconazole 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest[1][2][3].

IC50 & Target[2]

CYP3A4

 

体外研究
(In Vitro)

Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth[3].
Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton[1].
Antifungal Activities of Oxiconazole[1].

Candida
albicans		 Candida
glabrata		 Candida
parapsilosis		 Aspergillus
fumigatus		 Aspergillus
flavus		 Trichophyton
mentagrophytes		 Trichophyton
rubrum
Oxiconazole 0.03 μg/mL 0.01 μg/mL 0.008 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oxiconazole 相关抗体:

Cell Proliferation Assay[3]

Cell Line: HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460
Concentration: 0-40 μM
Incubation Time: 24 h
Result: Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC50s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.
体内研究
(In Vivo)

Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)[3]
Dosage: 50 mg/kg/day
Administration: IP; for 12 days
Result: Significantly restrained CRC cell growth and showed no obvious side effects.
Clinical Trial
分子量

429.13

Formula

C18H13Cl4N3O
CAS 号
中文名称

奥昔康唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Oxiconazole 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxiconazole64211-45-6Ro 13-8996奥昔康唑FungalCytochrome P450AntibioticCYPsAntifungalCYP3A4Rifampicincolorectal cancerPRDX2HCT116BALB/c nude miceInhibitorinhibitorinhibit

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