2. Anti-infection Metabolic Enzyme/Protease
  3. Fungal Cytochrome P450 Antibiotic
  4. Oxiconazole

Oxiconazole  (Synonyms: 奥昔康唑; Ro 13-8996 free base)

目录号: HY-B1324A
产品使用指南

摩尔计算器

Oxiconazole (Ro 13-8996) 是一种广谱抗真菌剂，能抑制念珠菌 (Candida)、曲霉属真菌 (Aspergillus) 和毛癣菌属真菌 (Trichophyton) 的生长。Oxiconazole 也是一种高效的 CYP3A4 反式激活剂，可与利福平 (Rifampicin; HY-B0272) 竞争性拮抗。Oxiconazole 通过过氧化物酶 2 (PRDX2) 介导的细胞自噬 (autophagy) 停滞来发挥抗结直肠癌的作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Oxiconazole Chemical Structure

Oxiconazole Chemical Structure

CAS No. : 64211-45-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Oxiconazole 的其他形式现货产品:

Customer Review

Other Forms of Oxiconazole:

Oxiconazole 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

查看 Antibiotic 亚型特异性产品:

查看所有亚型
Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest[1][2][3].

IC50 & Target[2]

CYP3A4

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
BV-2 EC50
13.5 μM
Compound: Oxiconazole
Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis
Inhibition of LPS induced NO production in mouse BV-2 cells by Griess reagent based analysis
[PMID: 34875520]
体外研究
(In Vitro)

Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth[3].
Oxiconazole has antifungal activity against Candida, Aspergillus and Trichophyton[1].
Antifungal Activities of Oxiconazole[1].

Candida
albicans		 Candida
glabrata		 Candida
parapsilosis		 Aspergillus
fumigatus		 Aspergillus
flavus		 Trichophyton
mentagrophytes		 Trichophyton
rubrum
Oxiconazole 0.03 μg/mL 0.01 μg/mL 0.008 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL 2 μg/mL

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Oxiconazole 相关抗体:

Cell Proliferation Assay[3]

Cell Line: HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460
Concentration: 0-40 μM
Incubation Time: 24 h
Result: Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC50s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.
体内研究
(In Vivo)

Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice (injected subcutaneously with HCT116 cells (1×107/mouse)[3]
Dosage: 50 mg/kg/day
Administration: IP; for 12 days
Result: Significantly restrained CRC cell growth and showed no obvious side effects.
Clinical Trial
分子量

429.13

Formula

C18H13Cl4N3O
CAS 号
中文名称

奥昔康唑
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Oxiconazole 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxiconazole64211-45-6Ro 13-8996奥昔康唑FungalCytochrome P450AntibioticCYPsAntifungalCYP3A4Rifampicincolorectal cancerPRDX2HCT116BALB/c nude miceInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Oxiconazole
目录号：
HY-B1324A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z