2. Cell Cycle/DNA Damage
  3. RAD51
  4. RI-2

RI-2 是一种可逆的 RAD51 抑制剂，IC50 值为 44.17 μM，能够特异性地抑制人体细胞中的同源重组修复。

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RI-2 Chemical Structure

RI-2 Chemical Structure

CAS No. : 1417162-36-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2585
In-stock
1 mg ￥1068
In-stock
5 mg ￥2350
In-stock
10 mg ￥4000
In-stock
100 mg 询价

* Please select Quantity before adding items.

RI-2 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.

IC50 & Target

IC50: 44.17 μM (RAD51)[1]
体外研究
(In Vitro)

RI-2 (7a) is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RI-2 相关抗体:
分子量

433.28

Formula

C21H18Cl2N2O4
CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 130 mg/mL (300.04 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3080 mL 11.5399 mL 23.0798 mL
5 mM 0.4616 mL 2.3080 mL 4.6160 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.90%

COA (294 KB) LCMS (88 KB)

产品使用指南 (1538 KB)
参考文献
Cell Assay
[1]

HEK293 cells are plated into 96-well tissue culture plates at a density of 300 cells per well in the presence or absence of 50 nM mitomycin C (MMC) for 24 hours at 37°C, 5% CO2. Media is subsequently replaced with fresh media containing 0.5% DMSO plus RI-2 for an additional 24 hours. RI-2 is then removed, and cultures are allowed to grow to a 50-70% confluence. Average survival from at least three replicates is measured using CellGlo reagentor. RI-2 is deemed successful in sensitizing cells to MMC if they generate significantly greater toxicity in the presence of MMC relative to the absence of MMC. Specifically, sensitization is scored as a “+” when non-overlapping standard errors are observed for at least two pairs of compound doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

RI-2 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3080 mL 11.5399 mL 23.0798 mL 57.6994 mL
5 mM 0.4616 mL 2.3080 mL 4.6160 mL 11.5399 mL
10 mM 0.2308 mL 1.1540 mL 2.3080 mL 5.7699 mL
15 mM 0.1539 mL 0.7693 mL 1.5387 mL 3.8466 mL
20 mM 0.1154 mL 0.5770 mL 1.1540 mL 2.8850 mL
25 mM 0.0923 mL 0.4616 mL 0.9232 mL 2.3080 mL
30 mM 0.0769 mL 0.3847 mL 0.7693 mL 1.9233 mL
40 mM 0.0577 mL 0.2885 mL 0.5770 mL 1.4425 mL
50 mM 0.0462 mL 0.2308 mL 0.4616 mL 1.1540 mL
60 mM 0.0385 mL 0.1923 mL 0.3847 mL 0.9617 mL
80 mM 0.0288 mL 0.1442 mL 0.2885 mL 0.7212 mL
100 mM 0.0231 mL 0.1154 mL 0.2308 mL 0.5770 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RI-21417162-36-7RI2RI 2RAD51Inhibitorinhibitorinhibit

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目录号：
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