2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Rauwolscine hydrochloride

Rauwolscine hydrochloride  (Synonyms: 萝芙素盐酸盐; α-Yohimbine hydrochloride; Corynanthidine hydrochloride; Isoyohimbine hydrochloride)

目录号: HY-12710A
COA 产品使用指南

摩尔计算器

Rauwolscine hydrochloride是高效，选择性的 α2 adrenergic 受体拮抗剂，Ki 值为12 nM。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Rauwolscine 通常具有更好的水溶性和稳定性。

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Rauwolscine hydrochloride Chemical Structure

Rauwolscine hydrochloride Chemical Structure

CAS No. : 6211-32-1

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Rauwolscine hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Rauwolscine hydrochloride:

Rauwolscine hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rauwolscine hydrochloride is a potent and specific α2 adrenergic receptor antagonist with a Ki of 12 nM.

IC50 & Target

Ki: 12 nM (α2 adrenergic receptor)[1]
体外研究
(In Vitro)

[3H]Rauwolscine binding to α2 adrenergic receptor is reversible, stcreospccific, and saturable. [3H]Rauwolscine specifically labels both the high and low affinity states of the α2 adrenergic receptor in brain membranes[1]. [3H]Rauwolscine also behaves as a 5-HT1A receptor agonist and this conclusion is compatible with earlier functional studies, indicating that rauwolscine (as well as yohimbine) has agonistic properties at the level of 5-HT autoreceptors[2]. When using [3H]5-HT as a radioligand, rauwolscine is determined to have relatively high affinity for the human receptor (Ki human=14.3 nM, Ki rat=35.8 nM)[3]. Saturation studies shows that the affinity of [3H]Rauwolscine is similar in mouse, rat, rabbit, dog (2.33-3.03 nM) except man where it is significantly higher (0.98 nM) [4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Rauwolscine hydrochloride 相关抗体:
分子量

390.90

Formula

C21H27ClN2O3
CAS 号
性状

固体

颜色

White to off-white

中文名称

萝芙素；育亨宾碱；洛芙素盐酸盐；萝芙素盐酸盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 12.5 mg/mL (31.98 mM; 超声助溶 (<80°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

H2O 中的溶解度 : 5 mg/mL (12.79 mM; 超声助溶 (<60°C))

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5582 mL 12.7910 mL 25.5820 mL
5 mM 0.5116 mL 2.5582 mL 5.1164 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Kinase Assay
[1]

Fresh bovine frontal cortex is incubated in triplicate with [3H]Rauwolscine (82 Ci/mM, diluted). Incubation is terminated by filtration under reduced pressure over filters, which are then rinsed with ice cold Tris-HCl buffer, dried overnight and added to disposable glass minivials containing 3.0 mL of a 95% Econofluor/5% Protosol solution. Samples are counted by liquid scintillation spectrometry with an efficiency of 32%. (-)- [3H]Epinephrine binding to bovine cortex membranes is conducted at 25°C[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Rauwolscine hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.5582 mL 12.7910 mL 25.5820 mL 63.9550 mL
5 mM 0.5116 mL 2.5582 mL 5.1164 mL 12.7910 mL
10 mM 0.2558 mL 1.2791 mL 2.5582 mL 6.3955 mL
DMSO 15 mM 0.1705 mL 0.8527 mL 1.7055 mL 4.2637 mL
20 mM 0.1279 mL 0.6395 mL 1.2791 mL 3.1977 mL
25 mM 0.1023 mL 0.5116 mL 1.0233 mL 2.5582 mL
30 mM 0.0853 mL 0.4264 mL 0.8527 mL 2.1318 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rauwolscine6211-32-1α-YohimbineCorynanthidineIsoyohimbine萝芙素育亨宾碱洛芙素盐酸盐萝芙素盐酸盐Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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