2. MAPK/ERK Pathway
  3. Ribosomal S6 Kinase (RSK)
  4. SL 0101-1

SL 0101-1  (Synonyms: SL0101)

目录号: HY-15237 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

SL 0101-1 (SL0101) 是从热带植物F. refracta 中提取得到的山萘酚糖苷，是能穿透细胞的、选择性的、可逆的、ATP竞争性的 p90核糖体S6激酶(RSK) 的抑制剂，其IC50 值为 89 nM。SL 0101-1 (SL0101) 是选择性的 RSK1/2 抑制剂，其 Ki 值为 1 μM。

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SL 0101-1 Chemical Structure

SL 0101-1 Chemical Structure

CAS No. : 77307-50-7

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥6704
In-stock
1 mg ￥1900
In-stock
5 mg ￥5900
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

Customer Review

SL 0101-1 相关抗体

Top Publications Citing Use of Products

查看 Ribosomal S6 Kinase (RSK) 亚型特异性产品:

查看所有亚型
p70S6K RSK1 RSK2 RSK3 RSK4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM[2].

IC50 & Target

RSK1

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCC70 IC50
15 μM
Compound: 52; SL0101
Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
[PMID: 33650861]
MCF7 IC50
45.6 μM
Compound: 1, SL0101
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
[PMID: 22464132]
MDA-MB-231 IC50
3 μM
Compound: 52; SL0101
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
[PMID: 33650861]
Sf9 IC50
0.583 μM
Compound: 1, SL0101
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
[PMID: 22464132]
Sf9 IC50
0.99 μM
Compound: 1, SL0101
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
[PMID: 23519677]
Sf9 IC50
89 nM
Compound: SL0101
Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
[PMID: 25147152]
体外研究
(In Vitro)

SL 0101-1 (SL0101) shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G1 phase[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SL 0101-1 相关抗体:
分子量

516.45

Formula

C25H24O12
CAS 号
性状

固体

颜色

White to yellow

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 10 mg/mL (19.36 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.9363 mL 9.6815 mL 19.3630 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥98.0%

COA (296 KB)

产品使用指南 (1538 KB)
参考文献

SL 0101-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9363 mL 9.6815 mL 19.3630 mL 48.4074 mL
5 mM 0.3873 mL 1.9363 mL 3.8726 mL 9.6815 mL
10 mM 0.1936 mL 0.9681 mL 1.9363 mL 4.8407 mL
15 mM 0.1291 mL 0.6454 mL 1.2909 mL 3.2272 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SL 0101-177307-50-7SL0101SL 0101SL-0101Ribosomal S6 Kinase (RSK)S6KInhibitorinhibitorinhibit

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目录号：
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