2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. GHR

GHR 

Growth Hormone Receptor; Somatotropin Receptor; Growth Hormone Binding Protein (GHBP)

Growth hormone (GH), also known as somatotropin, promotes body growth by binding with two GH receptors (GHRs) at the cell surface. GHRs interact with Janus kinase, signal transducers, and transcription activators to stimulate metabolic effects and insulin-like growth factor (IGF) synthesis. However, process dysfunctions in the GH–GHR–IGF-1 axis cause animal dwarfism. If, during the GH process, GHR is not successfully recognized and/or bound, or GHR fails to transmit the GH signal to IGF-1, the GH dysfunction occurs.

GHR 相关产品 (7):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-164419A
    Atesidorsen sodium Inhibitor
    Atesidorsen sodium 是一种反义寡核苷酸，可抑制人生长激素受体(GHR) mRNA的翻译。
    Atesidorsen sodium
  • HY-153485
    Cimdelirsen Inhibitor
    Cimdelirsen 是一种肝脏靶向的反义寡核苷酸，减少生长激素受体(GHr)的合成，从而抑制生长激素(GH)高分泌的有害影响，降低肢端肥大症患者循环胰岛素样生长因子-1 (IGF-1)的水平。
    Cimdelirsen
  • HY-RS05412
    GHR Human Pre-designed siRNA Set A Inhibitor
    GHR Human Pre-designed siRNA Set A 包括针对 GHR (Human) 基因的不同区域设计三对 siRNA，以及阴性对照、FAM 标记阴性对照和阳性对照。
    GHR Human Pre-designed siRNA Set A
    GHR Human Pre-designed siRNA Set A
  • HY-153485A
    Cimdelirsen sodium Inhibitor
    Cimdelirsen (sodium) 是一种肝脏靶向的反义寡核苷酸，减少生长激素受体(GHr)的合成，从而抑制生长激素(GH)高分泌的有害影响，降低肢端肥大症患者循环胰岛素样生长因子-1 (IGF-1)的水平。
    Cimdelirsen sodium
  • HY-164419
    Atesidorsen Inhibitor
    Atesidorsen 是一种反义寡核苷酸，可抑制人生长激素受体 (GHR) mRNA的翻译。
    Atesidorsen
  • HY-159697
    ISIS 532401
    ISIS 532401 是一种寡核苷酸，可以靶向 GHr。
    ISIS 532401
  • HY-159697A
    ISIS 532401 sodium
    ISIS 532401 sodium 是一种寡核苷酸，可以靶向 GHr。
    ISIS 532401 sodium
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