HMG Family (高迁移率族蛋白家族)

The high mobility group (HMG) proteins are a superfamily of abundant and ubiquitous nuclear proteins that bind to DNA and nucleosomes and induce structural changes in the chromatin fiber. HMG family proteins include HMGB, HMGN, and HMGA subfamilies, which are highly evolutionarily conserved nuclear proteins. The three HMG families in modulating developmental processes and tumorigenesis. As the most abundant protein among all the HMG family members and the second-most abundant protein in the nucleus, HMGB1 (also known as HMG1, HMG-1, and amphoterin) is widely expressed in mammalian cells and tissues. HMGB1 is a type of alarm signal protein that promotes the recruitment and activation of inflammation-promoting immune cells. HMG proteins is developmentally regulated and that changes in HMG protein levels alter the cellular phenotype and can lead to de