2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. YM17E

YM17E 是一种酰基辅酶a:胆固醇酰基转移酶 (ACAT) 的抑制剂，在兔肝微粒体的体外实验中，IC50 值为 44 nM。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

YM17E Chemical Structure

YM17E Chemical Structure

CAS No. : 124900-72-7

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥380
In-stock
5 mg ￥780
In-stock
10 mg ￥1100
In-stock
25 mg ￥1800
In-stock
50 mg ￥2600
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

YM17E 相关抗体

Top Publications Citing Use of Products

查看 Acyltransferase 亚型特异性产品:

查看所有亚型
ACAT1 ACAT2 MGAT2 ACAT

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro.

IC50 & Target

IC50: 44 nM (ACAT in rabbit liver microsomes)[1]
体外研究
(In Vitro)

YM17E is as potent in inhibiting ACAT activity in the liver as in the intestine, with IC50 values of 45 and 34 nM, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YM17E 相关抗体:
体内研究
(In Vivo)

YM17E (3, 10 and 30 mg/kg per day, p.o.) decreases total cholesterol, cholesteryl ester and non-HDL cholesterol in a dose-dependent manner. Total cholesterol and cholesteryl ester levels in liver do not decrease significantly after intravenous administration of YM17E, but do decrease significantly and in a dose-dependent manner after oral administration. YM17E (3, 5, 10 mg/kg, i.v.) significantly inhibits hepatic ACAT activities in a dose-dependent manner. YM17E produces a significant increase in 125I-LDL clearance in atherogenic diet-fed rats after both oral and intravenous administration[1]. YM17E inhibits production of [14C]cholesteryloleate from [14C]oleoyl CoA in a dose-dependent manner in both liver and intestinal microsomes used as enzyme sources[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

652.91

Formula

C40H56N6O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 125 mg/mL (191.45 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5316 mL 7.6580 mL 15.3160 mL
5 mM 0.3063 mL 1.5316 mL 3.0632 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.34%

COA (260 KB) HNMR (283 KB) LCMS (283 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

YM17E is administered to rats fed an atherogenic diet at intravenous doses of 0, 3, 5 and 10 mg/kg per day for 5 days or oral doses of 0, 3, 10 and 30 mg/kg per day for 5 days. At 2 h after final administration, all the blood and liver are removed. Serum is obtained from the blood by centrifugation and serum total cholesterol and free cholesterol are measured by an enzymatic method. Serum HDL is prepared by the heparin-Mn method.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

YM17E 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5316 mL 7.6580 mL 15.3160 mL 38.2901 mL
5 mM 0.3063 mL 1.5316 mL 3.0632 mL 7.6580 mL
10 mM 0.1532 mL 0.7658 mL 1.5316 mL 3.8290 mL
15 mM 0.1021 mL 0.5105 mL 1.0211 mL 2.5527 mL
20 mM 0.0766 mL 0.3829 mL 0.7658 mL 1.9145 mL
25 mM 0.0613 mL 0.3063 mL 0.6126 mL 1.5316 mL
30 mM 0.0511 mL 0.2553 mL 0.5105 mL 1.2763 mL
40 mM 0.0383 mL 0.1915 mL 0.3829 mL 0.9573 mL
50 mM 0.0306 mL 0.1532 mL 0.3063 mL 0.7658 mL
60 mM 0.0255 mL 0.1276 mL 0.2553 mL 0.6382 mL
80 mM 0.0191 mL 0.0957 mL 0.1915 mL 0.4786 mL
100 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3829 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM17E124900-72-7AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
YM17E
目录号：
HY-101627
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z