2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. (-)-Cevimeline hydrochloride hemihydrate

(-)-Cevimeline hydrochloride hemihydrate  (Synonyms: (-)-SNI-2011; (-)-AF102B hydrochloride hemihydrate)

目录号: HY-76772B 纯度: 98.19%
COA 产品使用指南

摩尔计算器

(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) 是mAChR激动剂。

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(-)-Cevimeline hydrochloride hemihydrate Chemical Structure

(-)-Cevimeline hydrochloride hemihydrate Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥6720
In-stock
5 mg   询价  
10 mg   询价  

* Please select Quantity before adding items.

Other Forms of (-)-Cevimeline hydrochloride hemihydrate:

(-)-Cevimeline hydrochloride hemihydrate 相关抗体

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mAChR1 mAChR2 mAChR3 mAChR4 mAChR5

  • 生物活性

  • 纯度 & 产品资料

生物活性

(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011), a novel muscarinic receptor agonist, is a candidate therapeutic drug for xerostomia in Sjogren's syndrome. IC50 value: Target: mAChR The general pharmacol. properties of this drug on the gastrointestinal, urinary, and reproductive systems and other tissues were investigated in mice, rats, guinea pigs, rabbits, and dogs. The in vitro metab. of SNI-2011 was also evaluated with rat and dog liver microsomes. After oral administration, plasma concns. of SNI-2011 reached to Cmax within 1 h in both species, suggesting that SNI-2011 was quickly absorbed, and then decreased with a t1/2 of 0.4-1.1 h. The bioavailability was 50% and 30% in rats and dogs, resp. Major metabolites in plasma were both S- and N-oxidized metabolites in rats and only N-oxidized metabolite in dogs, indicating that a large species difference was obsd. in the metab. of SNI-2011. Sex difference was also obsd. in the pharmacokinetics of SNI-2011 in rats, but not in dogs. In the in vitro study, chem. inhibition and pH-dependent studies revealed that the sulfoxidn. and N-oxidn. of SNI-2011 were mediated by cytochrome P 450 (CYP) and flavin-contg. monooxygenase (FMO), resp., in both species. In addn., CYP2D and CYP3A were mainly responsible for the sulfoxidn. in rat liver microsomes.

分子量

244.78

Formula

C10H17NOS.HCl.1/2H2O
性状

固体

颜色

Light yellow to yellow

中文名称

(-)-盐酸西维美林半水合物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (408.53 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0853 mL 20.4265 mL 40.8530 mL
5 mM 0.8171 mL 4.0853 mL 8.1706 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

(-)-Cevimeline hydrochloride hemihydrate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.0853 mL 20.4265 mL 40.8530 mL 102.1325 mL
5 mM 0.8171 mL 4.0853 mL 8.1706 mL 20.4265 mL
10 mM 0.4085 mL 2.0427 mL 4.0853 mL 10.2133 mL
15 mM 0.2724 mL 1.3618 mL 2.7235 mL 6.8088 mL
20 mM 0.2043 mL 1.0213 mL 2.0427 mL 5.1066 mL
25 mM 0.1634 mL 0.8171 mL 1.6341 mL 4.0853 mL
30 mM 0.1362 mL 0.6809 mL 1.3618 mL 3.4044 mL
40 mM 0.1021 mL 0.5107 mL 1.0213 mL 2.5533 mL
50 mM 0.0817 mL 0.4085 mL 0.8171 mL 2.0427 mL
60 mM 0.0681 mL 0.3404 mL 0.6809 mL 1.7022 mL
80 mM 0.0511 mL 0.2553 mL 0.5107 mL 1.2767 mL
100 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(-)-Cevimeline hydrochloride hemihydrate(-)-SNI-2011(-)-AF102B hydrochloride hemihydrate(-)-盐酸西维美林半水合物mAChRMuscarinic acetylcholine receptorInhibitorinhibitorinhibit

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目录号：
HY-76772B
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