(+)-Viroallosecurinine

目录号: HY-N5002 纯度: ≥99.0%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

(+)-Viroallosecurinine 是一种细胞毒性生物碱，抑制 Ps. Aeruginosa 和 Staph. aureus，MIC 为 0.48 μg/mL。具有抗菌活性。

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(+)-Viroallosecurinine Chemical Structure

CAS No. : 1857-30-3

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规格	价格	是否有货
1 mg	￥2193	In-stock
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Other Forms of (+)-Viroallosecurinine:

Allosecurinine In-stock

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生物活性
纯度 & 产品资料
参考文献

生物活性

(+)-Viroallosecurinine, a cytotoxic alkaloid, exhibits a MIC of 0.48 μg/mL for Ps. Aeruginosa and Staph. aureus^[1]. Antibacterial activity^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-375	IC₅₀	6.1 μM Compound: 1	Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human A375 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
A-375	IC₅₀	6.1 μM Compound: 1	Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human A375 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
A549	IC₅₀	> 10 μM Compound: 1	Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
A549	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human A549 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
A549	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 31082231]
A549	IC₅₀	23.59 μM Compound: Securinine	Growth inhibition of human A549 cells after 72 hrs by MTT assay Growth inhibition of human A549 cells after 72 hrs by MTT assay	[PMID: 27344492]
A549	IC₅₀	25 μM Compound: 1	Cytotoxicity against human A549 cells after 72 hrs by Coulter counter analysis Cytotoxicity against human A549 cells after 72 hrs by Coulter counter analysis	[PMID: 26793989]
BV-2	IC₅₀	1.1 μM Compound: 12	Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay Antiinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitrite production after 24 hrs by Griess assay	[PMID: 31082231]
HCT-116	IC₅₀	> 10 μM Compound: 1	Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human HCT116 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
HCT-116	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human HCT116 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
HCT-15	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay	[PMID: 31082231]
HeLa	IC₅₀	50.23 μM Compound: Securinine	Growth inhibition of human HeLa cells after 72 hrs by MTT assay Growth inhibition of human HeLa cells after 72 hrs by MTT assay	[PMID: 27344492]
HepG2	IC₅₀	36.87 μM Compound: Securinine	Growth inhibition of human HepG2 cells after 72 hrs by MTT assay Growth inhibition of human HepG2 cells after 72 hrs by MTT assay	[PMID: 27344492]
HL-60	IC₅₀	> 10 μM Compound: 1	Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay Antiproliferative activity against human HL60 cells assessed as reduction in cell viability after 72 hrs by ATPlite assay	[PMID: 27096049]
HL-60	IC₅₀	> 10 μM Compound: 1	Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by ATPlite assay Cytotoxicity against human HL60 cells assessed as growth inhibition after 72 hrs by ATPlite assay	[PMID: 26793989]
MCF7	IC₅₀	25 μM Compound: 1	Antiproliferative activity against human MCF7 cells by CCK8 assay Antiproliferative activity against human MCF7 cells by CCK8 assay	[PMID: 27096049]
MCF7	IC₅₀	25 μM Compound: 1	Cytotoxicity against human MCF7 cells assessed as growth inhibition by CCK8 assay Cytotoxicity against human MCF7 cells assessed as growth inhibition by CCK8 assay	[PMID: 26793989]
SH-SY5Y	IC₅₀	78.9 μM Compound: Securinine	Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay Growth inhibition of human SH-SY5Y cells after 72 hrs by MTT assay	[PMID: 27344492]
SK-MEL-2	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay	[PMID: 31082231]
SK-OV-3	IC₅₀	> 10 μM Compound: 12	Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay Cytotoxicity against human SKOV3 cells after 48 hrs by SRB assay	[PMID: 31082231]
SW480	IC₅₀	25.855 μM Compound: Securinine	Antiproliferative activity against human SW480 cells after 48 hrs by MTT assay Antiproliferative activity against human SW480 cells after 48 hrs by MTT assay	[PMID: 27344492]

分子量

217.26

Formula

C₁₃H₁₅NO₂

CAS 号

1857-30-3

性状

固体

颜色

Light yellow to yellow

结构分类

初始来源

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

细胞实验：

DMSO 中的溶解度 : 22.5 mg/mL (103.56 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.6028 mL	23.0139 mL	46.0278 mL
5 mM	0.9206 mL	4.6028 mL	9.2056 mL
10 mM	0.4603 mL	2.3014 mL	4.6028 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: ≥99.0%

选择批次：

Data Sheet (605 KB) SDS (252 KB)

COA (300 KB) HNMR (298 KB) RP-HPLC (112 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Mensah JL, et al. Antibacterial activity of the leaves of Phyllanthus discoideus. J Ethnopharmacol. 1990 Feb;28(1):129-33. [Content Brief]

(+)-Viroallosecurinine 相关分类

Infection

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6028 mL	23.0139 mL	46.0278 mL	115.0695 mL
	5 mM	0.9206 mL	4.6028 mL	9.2056 mL	23.0139 mL
	10 mM	0.4603 mL	2.3014 mL	4.6028 mL	11.5070 mL
	15 mM	0.3069 mL	1.5343 mL	3.0685 mL	7.6713 mL
	20 mM	0.2301 mL	1.1507 mL	2.3014 mL	5.7535 mL
	25 mM	0.1841 mL	0.9206 mL	1.8411 mL	4.6028 mL
	30 mM	0.1534 mL	0.7671 mL	1.5343 mL	3.8357 mL
	40 mM	0.1151 mL	0.5753 mL	1.1507 mL	2.8767 mL
	50 mM	0.0921 mL	0.4603 mL	0.9206 mL	2.3014 mL
	60 mM	0.0767 mL	0.3836 mL	0.7671 mL	1.9178 mL
	80 mM	0.0575 mL	0.2877 mL	0.5753 mL	1.4384 mL
	100 mM	0.0460 mL	0.2301 mL	0.4603 mL	1.1507 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(+)-Viroallosecurinine1857-30-3BacterialInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

(+)-Viroallosecurinine

Customer Review

Other Forms of (+)-Viroallosecurinine:

(+)-Viroallosecurinine 相关产品

•同靶点产品:

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参考文献

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稀释计算器

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完整储备液配制表

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(+)-Viroallosecurinine

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(+)-Viroallosecurinine 相关抗体

(+)-Viroallosecurinine 相关产品

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生物活性

纯度 & 产品资料

参考文献

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(+)-Viroallosecurinine 相关分类

完整储备液配制表

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