2. Apoptosis
  3. Apoptosis
  4. ABT-510 acetate

ABT-510 acetate 是一种抗血管生成 TSP 肽 (thrombospondin-1 类似物)，能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 还可减少小鼠炎症性肠病模型的血管生成和炎症反应。ABT-510 acetate 可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。

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Custom Peptide Synthesis

ABT-510 acetate Chemical Structure

ABT-510 acetate Chemical Structure

CAS No. : 442526-87-6

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规格 价格 是否有货 数量
5 mg ￥1600
In-stock
10 mg ￥2600
In-stock
25 mg ￥5200
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100 mg   询价  

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Customer Review

Other Forms of ABT-510 acetate:

ABT-510 acetate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABT-510 acetate is an anti-angiogenic TSP peptide (Thrombospondin-1 analogue) that induces apoptosis and inhibits ovarian tumour growth in an orthotopic, syngeneic model of epithelial ovarian cancer. ABT-510 acetate also reduces angiogenesis and inflammatory responses in a murine model of inflammatory bowel disease. ABT-510 acetate can be used in studies of cancer (particularly epithelial ovarian cancer) and inflammatory bowel disease (IBD)[1][2].

体外研究
(In Vitro)

ABT-510 acetate (1，5，10，20，50 nM；24 h) 诱导 ID 8 细胞凋亡，增加人类上皮性癌症细胞系 SKOV3、OVCAR3 和 CAOV3 的凋亡发生率[1]。
ABT-510 acetate (0-10 μM；7 天) 抑制了 NO 刺激的血管细胞向细胞外基质的生长和侵袭。ABT-510 acetate 可阻断肿瘤驱动的血管细胞生长、NO 驱动的 cGMP 通量以及 CD36 介导的脂肪酸吸收。[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ABT-510 acetate 相关抗体:

Apoptosis Analysis[1]

Cell Line: ID8, SKOV3, OVCAR3, and CAOV3 cells
Concentration: 1, 5, 10, 20, 50 nM
Incubation Time: 24 h
Result: Induced ID8 cells apoptosis and increased in apoptosis in the human EOC cell lines SKOV3, OVCAR3, and CAOV3.

Cell Proliferation Assay[3]

Cell Line: Tissue biopsies of B16F10 melanoma tumors grown in C57BL/6 mice
Concentration: 0-10 μM
Incubation Time: 7 days
Result: Inhibited NO-stimulated vascular cell outgrowth into and invasion through extracellular matrix.
体内研究
(In Vivo)

ABT-510 acetate (100 mg/kg；腹腔注射；每天一次，持续90天) 在体内诱导细胞凋亡，使小鼠的上皮卵巢肿瘤大小、腹水量和继发性病变扩散显著减少[1]。
ABT-510 acetate (60 mg/kg；皮下渗透微型泵；每天一次，持续7天) 降低炎症性肠病小鼠模型中的血管生成和炎症[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: TSP-1-Null mice (C57BL/6 background; orthotopic, syngeneic model of epithelial ovarian cancer)[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; single daily for 90 days
Result: Reduced ovarian tumor growth in wild-type and TSP-1-Null Mice.
Significantly reduced the volume of ascites and completely abolished the formation of peritoneal lesions.
Reversed ovarian tumor hypervascularization and increased the proportion of mature blood vessels.
Animal Model: TSP-1-Null mice (C57BL/6 background; 6-week-old; DSS-induced inflammatory bowel disease murine model)[2]
Dosage: 60 mg/kg
Administration: Subcutaneously implanted osmotic minipumps (0.5µL/h); single daily for 7 days
Result: Significantly delayed DSS-induced bleeding and improved the overall severity of disease.
Significantly diminished inflammation grading and angiogenesis.
Clinical Trial
分子量

1054.28

Formula

C48H87N13O13
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 100 mg/mL (94.85 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.9485 mL 4.7426 mL 9.4851 mL
5 mM 0.1897 mL 0.9485 mL 1.8970 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

ABT-510 acetate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9485 mL 4.7426 mL 9.4851 mL 23.7129 mL
5 mM 0.1897 mL 0.9485 mL 1.8970 mL 4.7426 mL
10 mM 0.0949 mL 0.4743 mL 0.9485 mL 2.3713 mL
15 mM 0.0632 mL 0.3162 mL 0.6323 mL 1.5809 mL
20 mM 0.0474 mL 0.2371 mL 0.4743 mL 1.1856 mL
25 mM 0.0379 mL 0.1897 mL 0.3794 mL 0.9485 mL
30 mM 0.0316 mL 0.1581 mL 0.3162 mL 0.7904 mL
40 mM 0.0237 mL 0.1186 mL 0.2371 mL 0.5928 mL
50 mM 0.0190 mL 0.0949 mL 0.1897 mL 0.4743 mL
60 mM 0.0158 mL 0.0790 mL 0.1581 mL 0.3952 mL
80 mM 0.0119 mL 0.0593 mL 0.1186 mL 0.2964 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABT-510442526-87-6ABT510ABT 510Apoptosisanti-angiogenic inflammationIBDID8 cancer cellsABT-510，epithelial ovarian cancerInhibitorinhibitorinhibit

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