2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-29

AChE-IN-29，3-OH 吡咯烷衍生物，是一种胆碱酯酶 ChE 抑制剂。 AChE-IN-29 对 hAChE、eeAChE 和 eqBChE 具有胆碱酯酶抑制活性，IC50 值分别为 0.25 μM、0.23 μM 和 0.72 μM。 AChE-IN-29 可用于阿尔茨海默病的研究。

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AChE-IN-29 Chemical Structure

AChE-IN-29 Chemical Structure

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AChE-IN-29 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-29, 3-OH pyrrolidine derivative, is an cholinesterase (ChE) inhibitor. AChE-IN-29 has cholinesterase inhibitory activity for hAChE, eeAChE and eqBChE with IC50 values of 0.25 μM, 0.23 μM and 0.72 μM, respectively. AChE-IN-29 can be used for the research of Alzheimer's disease[1].

IC50 & Target

IC50: 0.25 μM (hAChE); 0.23 μM (eeAChE); eqBChE (0.72 μM); 24.12 μM (in DPPH assay)[1]
体外研究
(In Vitro)

AChE-IN-29 (VA10) 可有效抑制 AChE、BChE 和 Aβ1-42[1]。
AChE-IN-29 对 hAChE、eeAChE 和 eqBChE 具有胆碱酯酶抑制活性，IC50 值分别为 0.25 μM、0.23 μM 和 0.72 μM[1]。
AChE-IN-29 具有显著的抗氧化活性，在 DPPH 试验中的 IC50 值为 24.12 μM[1]。
AChE-IN-29（5 μM、10 μM、20 μM）可抑制自身诱导的 Aβ1-42 聚集以及 hAChE 诱导的 Aβ1-42 聚集[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-29 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells
Concentration: 5, 10, and 20 μM
Incubation Time: 72 h
Result: Reduced the Aβ1-42 aggregation and showed no toxic effects on tested cell line (SH-SY5Y).
体内研究
(In Vivo)

AChE-IN-29 (VA10) (p.o.; 2.5, 5, and 10 mg/kg) 通过抑制 AChE 活性改善记忆和认知功能障碍[1]。
AChE-IN-29 (p.o.; 10 mg/kg) 恢复海马区的细胞密度[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (200 ± 15 g)[1]
Dosage: 2.5, 5, and 10 mg/kg
Administration: p.o.; once a day for seven days
Result: Improved cognition and memory in the scopolamine-induced cholinergic deficit.
Restoresd the neuronal cells and can inhibit neuronal toxicity in AD conditions.
分子量

375.26

Formula

C18H19BrN2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-29 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-29Cholinesterase (ChE)pyrrolidine derivativehAChEeeAChEeqBChEvasicineacetylcholineAlzheimer's diseaseInhibitorinhibitorinhibit

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