2. Neuronal Signaling
  3. Cholinesterase (ChE) Amyloid-β
  4. AChE-IN-62

AChE-IN-62 (Compound 1) 是一种有效的混合型选择性乙酰胆碱酯酶 (AChE) 抑制剂，IC50 值为 0.421 μM。AChE-IN-62 具有良好的血脑屏障透过性和神经保护作用。AChE-IN-62 能抑制 Aβ1-42 的聚集，IC50 值为 44.64 μM。AChE-IN-62 也是一种有效的多靶点定向配体 (MTDL)，可以用于阿尔兹海默症的研究。

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AChE-IN-62 Chemical Structure

AChE-IN-62 Chemical Structure

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AChE-IN-62 相关抗体

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查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1-42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease[1].

IC50 & Target

IC50: 0.421 μM (AChE)[1].
体外研究
(In Vitro)

AChE-IN-62 (50 μM; 24-48 h) 能有效抑制 Aβ1−42 的聚集，IC50 值为 44.64 μM[1]。
AChE-IN-62 (5-20 μM; 24 h) 在 SH-SY5Y 和 Neuro2A 细胞中，能够改善 H2O2 (200 μM; 24 h) 和 Okadaic acid (HY-N6785) (30 nM; 24 h) 介导的细胞神经毒性，具有神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-62 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y, Neuro2A
Concentration: 5 μM, 10 μM, 20 μM;
Incubation Time: 24 h
Result: Inhibited the cell death mediated by H2O2 (200 μM; 24 h) and Okadaic acid (HY-N6785).
体内研究
(In Vivo)

AChE-IN-62 (Compound 1) ( 10-20 mg/kg; 腹腔注射; 一天一次连续 7 天) 在瑞士白化痴呆小鼠中通过修复大脑皮层和海马组织的损伤来改善 Scopolamine (HY-N0296) (3 mg/kg; 腹腔注射; 一天一次连续 7 天) 诱导的记忆力下降和学习障碍，对 Scopolamine (HY-N0296) 造成的伤害起到了保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dementia model of Swiss albino mice mediated by scopolamine[1].
Dosage: 5 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 7 days. Before scopolamine (HY-N0296) treatment (3 mg/kg; i.p.; Once daily for 7 days)
Result: Reduced the recognition ratio (T2/T1) in mice (a lower T2/T1 value indicates stronger short-term recognition memory).
Significantly enhanced the step-through latency (STL) (a decrease in STL indicates impaired memory).
分子量

431.53

Formula

C19H21N5O3S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-62 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-62Cholinesterase (ChE)Amyloid-ββ-amyloid peptideAβAbetaAlzheimer’s disease (AD)multi-target- directed ligand (MTDL)SH-SY5Ymulti-target- directed ligand (MTDL)Neuro2ABlood-Brain Barrier (BBB)neuroprotectionInhibitorinhibitorinhibit

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