2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. α-Zearalenol

α-Zearalenol 是一种对雌激素受体 (ER) 具有高亲和力的霉菌毒素, α-Zearalenol 是 zearalenone (ZEN) 的衍生物，由于其异种雌激素效应可引起动物的生殖障碍。

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α-Zearalenol Chemical Structure

α-Zearalenol Chemical Structure

CAS No. : 36455-72-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥3080
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1 mg ￥1066
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5 mg ￥2800
In-stock
10 mg ￥4200
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100 mg   询价  

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Customer Review

Other Forms of α-Zearalenol:

α-Zearalenol 相关抗体

Top Publications Citing Use of Products

查看 Estrogen Receptor/ERR 亚型特异性产品:

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

α-Zearalenol is a Mycotoxin with high affinity for the estrogen receptors (ER), α-Zearalenol is the derivative of zearalenone (ZEN), causes reproductive disorders in animals, due to its xenoestrogenic effects[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
KB IC50
100.29 μM
Compound: 18
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
Cytotoxicity against human KB cells assessed as reduction in cell viability by resazurin microplate assay
[PMID: 27311894]
Vero IC50
60.33 μM
Compound: 18
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability by green fluorescent protein-based assay
[PMID: 27311894]
体外研究
(In Vitro)

α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) shows the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells with an IC50 of 12.5 μM[1].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) induces an increase of cell viability on MCF-7 cells mainly after 72 h of treatment whereas it is slightly cytotoxic on MDA-MB231 cells[2].
α-Zearalenol (α-zol) (0.001-10 μM; 24-72 hours) increases MCF7 cell population in the S phase and in the G2/M phase, no visible change in cell cycle phases is observed in MDA-MB231 cells[2].
α-Zearalenol (α-zol) (1-10 μM; 24 hours) reduces the expression of TNF-α, α-ZOL combines with β-ZOL shows an antagonistic effect on inflammation for IL-1β and act synergic for IL-8 at high toxin concentrations[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

α-Zearalenol 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MFC-7 cells
Concentration: 6.25 µM-25 µM
Incubation Time: 24 hours
Result: Observed the highest RPE (90.5%) at 9.37 µM α-ZOL exposure in MFC-7 cells.

Cell Viability Assay[2]

Cell Line: Breast cancer cell lines: MCF-7 and MDA-MB231
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Modified the cell growth in two breast cancer cell lines.

Cell Cycle Analysis[2]

Cell Line: MCF7 cells, MDA-MB231 cells
Concentration: 0.001 μM, 0.1 μM and 10 μM
Incubation Time: 72 hours
Result: Observed an increase of cells in cell cycle in MCF7 cells.

RT-PCR[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 5 μM, 10 μM
Incubation Time: 72 hours
Result: Induced a decrease of the expression of TNF-α, IL-1β and IL-8, that was in most cases statistically significant for the higher doses.
分子量

320.38

Formula

C18H24O5
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (312.13 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1213 mL 15.6065 mL 31.2129 mL
5 mM 0.6243 mL 3.1213 mL 6.2426 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.63%

COA (265 KB) LCMS (269 KB)

产品使用指南 (1538 KB)
参考文献

α-Zearalenol 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1213 mL 15.6065 mL 31.2129 mL 78.0323 mL
5 mM 0.6243 mL 3.1213 mL 6.2426 mL 15.6065 mL
10 mM 0.3121 mL 1.5606 mL 3.1213 mL 7.8032 mL
15 mM 0.2081 mL 1.0404 mL 2.0809 mL 5.2022 mL
20 mM 0.1561 mL 0.7803 mL 1.5606 mL 3.9016 mL
25 mM 0.1249 mL 0.6243 mL 1.2485 mL 3.1213 mL
30 mM 0.1040 mL 0.5202 mL 1.0404 mL 2.6011 mL
40 mM 0.0780 mL 0.3902 mL 0.7803 mL 1.9508 mL
50 mM 0.0624 mL 0.3121 mL 0.6243 mL 1.5606 mL
60 mM 0.0520 mL 0.2601 mL 0.5202 mL 1.3005 mL
80 mM 0.0390 mL 0.1951 mL 0.3902 mL 0.9754 mL
100 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Zearalenol36455-72-8Estrogen Receptor/ERRInhibitorinhibitorinhibit

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