2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. Aminoxyacetic acid

Aminoxyacetic acid  (Synonyms: Carboxymethoxylamine; Aminooxyacetate)

目录号: HY-107994A
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摩尔计算器

Aminooxyacetic acid (Carboxymethoxylamine) 是苹果酸-天冬氨酸穿梭 (MAS) 抑制剂, 也能抑制 GABA 降解酶 GABA-T。

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Aminoxyacetic acid Chemical Structure

Aminoxyacetic acid Chemical Structure

CAS No. : 645-88-5

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Aminoxyacetic acid 的其他形式现货产品:

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Other Forms of Aminoxyacetic acid:

Aminoxyacetic acid 相关抗体

Top Publications Citing Use of Products

    Aminoxyacetic acid purchased from MCE. Usage Cited in: Signal Transduct Target Ther. 2023 Feb 15;8(1):65.  [Abstract]

    Aminooxyacetic acid hemihydrochloride (AOA; 20 μM; 48 h) decreases the migration and invasion of HCC cells expressing p5372P variant (fig C and D).

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Aminooxyacetic acid (Carboxymethoxylamine) is a malate-aspartate shuttle (MAS) inhibitor. Aminooxyacetic acid also inhibits the GABA degradating enzyme GABA-T.

    IC50 & Target

    MAS[1], GABA-T[2]
    体外研究
    (In Vitro)

    Aminooxyacetic acid (AOAA) 剂量依赖性地降低 C6 神经胶质瘤细胞的存活。Aminoxyacetic acid 处理使停滞在 G0/G1 期的细胞百分比显着增加，并使处于 S 期和 G2/M 期的细胞百分比显着降低。Aminoxyacetic acid 处理导致处于细胞分裂期的细胞数量明显减少。Aminoxyacetic acid 显着增加早期细胞凋亡和坏死的百分比。用 1mM 或 5mM Aminoxyacetic acid 处理细胞可降低细胞老化水平[1]。与谷氨酰胺依赖性较低的细胞相比，Aminoxyacetic acid (AOA) 对谷氨酰胺依赖性细胞系生长的抑制作用更大[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Aminoxyacetic acid 相关抗体:
    体内研究
    (In Vivo)

    GABA 在小脑和整个大脑中的积累最初非常迅速，在注射 Aminooxyacetic acid (AOAA) 后 5 分钟就已经显著增加。Aminooxyacetic acid 处理后 2 至 6 小时，GABA 快速的初始积累逐渐变慢并达到最大水平（对照水平的 400 至 600%）。Aminooxyacetic acid 处理后 24 小时，GABA 水平升高了约 250%。Aminooxyacetic acid 处理后 2-6小时，惊厥完全阻断。Aminooxyacetic acid 处理后 24 小时，惊厥与对照组几乎相同[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    91.07

    Formula

    C2H5NO3
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Aminoxyacetic acid 相关分类

    • 摩尔计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Aminoxyacetic acid645-88-5Carboxymethoxylamine AminooxyacetateGABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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