2. Membrane Transporter/Ion Channel
  3. Chloride Channel
  4. Ani9

Ani9 是一种 ANO1 抑制剂， IC50 为 77 nM。Ani9 可抑制小鼠平滑肌收缩，且可应用于肿瘤等疾病的研究。

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Ani9 Chemical Structure

Ani9 Chemical Structure

CAS No. : 356102-14-2

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规格 价格 是否有货 数量
1 mg ￥535
In-stock
5 mg ￥1250
In-stock
10 mg ￥2000
In-stock
25 mg ￥4200
In-stock
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500 mg 现货 询价
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Customer Review

Ani9 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ani9 is an ANO1 inhibitor, with an IC50 of 77 nM. Ani9 can inhibit smooth muscle contractions in mice and is applicable in research related to diseases such as tumors[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
U138-MG GI50
32.44 μM
Compound: 3
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U138 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
18.06 μM
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability in presence of temozolomide measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-251 GI50
36.48 μM
Compound: 3
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U251 cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
U-87MG ATCC GI50
32.98 μM
Compound: 3
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
Antiproliferative activity against human U87MG cells overexpressing ANO1 assessed as reduction in cell viability measured after 72 hrs by Celltiter-glo assay
[PMID: 32906067]
体外研究
(In Vitro)

Ani9 (0-30 μM，20 min) 不影响 ATP 诱导的 FRT 细胞胞质钙增加[1]。
Ani9 (1-10 μM，20 min) 抑制 ANO1[1]。
Ani9 (0.03-10 μM，20 min) 在 PC3，Capan-1，NHNE 细胞中抑制 CaCC 电流，且呈剂量依赖性，IC50 为 110 nM[1]。
Ani9 (0-10 μM，24 h) 在 PC3 细胞中高表达 ANO1[2]。
Ani9 (0.01-10 μM，48 h) 对前列腺癌，乳腺癌和胰腺癌细胞的抑制作用较弱[2]。
Ani9 (1 μM) 在 Cav1-KO 小鼠的门静脉平滑肌中抑制 Ca2+ 激活 Cl- (Clca)[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Ani9 相关抗体:

Western Blot Analysis[2]

Cell Line: PC3
Concentration: 0, 3, 10 μM
Incubation Time: 24 h
Result: Expressed ANO1.

Cell Viability Assay[2]

Cell Line: PC3, MCF-7, BxPC3
Concentration: 0.01, 0.1, 1, 10 μM
Incubation Time: 48 h
Result: Had a weak inhibitory effect on cells.
分子量

332.78

Formula

C17H17ClN2O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 125 mg/mL (375.62 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0050 mL 15.0249 mL 30.0499 mL
5 mM 0.6010 mL 3.0050 mL 6.0100 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Ani9 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0050 mL 15.0249 mL 30.0499 mL 75.1247 mL
5 mM 0.6010 mL 3.0050 mL 6.0100 mL 15.0249 mL
10 mM 0.3005 mL 1.5025 mL 3.0050 mL 7.5125 mL
15 mM 0.2003 mL 1.0017 mL 2.0033 mL 5.0083 mL
20 mM 0.1502 mL 0.7512 mL 1.5025 mL 3.7562 mL
25 mM 0.1202 mL 0.6010 mL 1.2020 mL 3.0050 mL
30 mM 0.1002 mL 0.5008 mL 1.0017 mL 2.5042 mL
40 mM 0.0751 mL 0.3756 mL 0.7512 mL 1.8781 mL
50 mM 0.0601 mL 0.3005 mL 0.6010 mL 1.5025 mL
60 mM 0.0501 mL 0.2504 mL 0.5008 mL 1.2521 mL
80 mM 0.0376 mL 0.1878 mL 0.3756 mL 0.9391 mL
100 mM 0.0300 mL 0.1502 mL 0.3005 mL 0.7512 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ani9356102-14-2Ani 9Ani-9Chloride ChannelCl− ChannelsAnoctamin 1 (ANO1)InhibitorAnticancer agentinhibitorinhibit

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