2. Apoptosis Epigenetics
  3. Histone Methyltransferase Apoptosis
  4. Antiproliferative agent-25

Antiproliferative agent-25 (Compound 3s4) 是一种选择性的 PRMT5 抑制剂 (IC50: 0.11 μM)。Antiproliferative agent-25 上调 hnRNP E1 蛋白水平。Antiproliferative agent-25 与 SAM 和 PRMT5 的 E444 残基形成氢键相互作用。Antiproliferative agent-25 通过诱导细胞凋亡 (apoptosis) 和抑制细胞迁移来抑制 A549 细胞增殖。Antiproliferative agent-25 在人和大鼠肝微粒体中具有高清除率，T1/2 仅为 21.8 和 4.7 分钟。

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Antiproliferative agent-25 Chemical Structure

Antiproliferative agent-25 Chemical Structure

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Antiproliferative agent-25 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antiproliferative agent-25 (Compound 3s4) is a selective PRMT5 inhibitor (IC50: 0.11 μM). Antiproliferative agent-25 up-regulates hnRNP E1 protein level. Antiproliferative agent-25 forms H-bond interactions with SAM and E444 residue of PRMT5. Antiproliferative agent-25 has antiproliferative effects against A549 cells by inducing apoptosis and inhibiting cell migration. Antiproliferative agent-25 has high clearances with T1/2 of only 21.8 and 4.7 min in human and rat liver microsomes[1].

IC50 & Target

0.11 μM (PRMT5)[1]
分子量

401.30

Formula

C20H21BrN2O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antiproliferative agent-25 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antiproliferative agent-25Antiproliferative agent25Antiproliferative agent 25Histone MethyltransferaseApoptosisA549liver microsomecancerantiproliferativecell migrationInhibitorinhibitorinhibit

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