2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Cytochrome P450 Caspase Reactive Oxygen Species
  4. Apoptosis inducer 30

Apoptosis inducer 30 (Compound 15a) 是一种抗癌剂。Apoptosis inducer 30 通过线粒体途径诱导 MCF-7 细胞凋亡 (Apoptosis)。Apoptosis inducer 30 诱导细胞内活性氧水平升高，并降低线粒体膜电位，并将细胞周期阻滞在 G0/G1 期。Apoptosis inducer 30 抑制细胞生长，对 MCF-7 细胞的 IC50 值为 0.32 μM，并抑制小鼠乳腺癌模型中的肿瘤生长。

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Apoptosis inducer 30 Chemical Structure

Apoptosis inducer 30 Chemical Structure

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Apoptosis inducer 30 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 30 (Compound 15a) is an anticancer agent. Apoptosis inducer 30 induces MCF-7 cells apoptosis through mitochondrial pathway. Apoptosis inducer 30 induces intracellular reactive oxygen species levels and decreases mitochondrial membrane potential, and blocks the cell cycle in the G0/G1 phase. Apoptosis inducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and inhibits tumor growth in a mouse model of breast cancer[1].

IC50 & Target[1]

Caspase-9

 

Caspase-7

 

体外研究
(In Vitro)

Apoptosis inducer 30 抑制肿瘤细胞生长，对 A549、HepG2、MCF-7、HeLa、MCF-10A 细胞的 IC50 分别为 1.01、0.91、0.32、0.95、8.09 μM[1]。
Apoptosis inducer 30 (100-500 nM, 48 小时) 增加 MCF-7 细胞质中的 Cyt-C 水平，并激活 caspase-9 和 caspase-7[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 30 相关抗体:
分子量

882.99

Formula

C52H69BrNO4P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 30 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 30Apoptosis inducer30Apoptosis inducer-30ApoptosisCytochrome P450CaspaseReactive Oxygen SpeciesCYPsInhibitorinhibitorinhibit

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