2. GPCR/G Protein
  3. Endothelin Receptor
  4. ATZ-1993

ATZ-1993 是一种具有口服活性的，非肽类内皮素受体亚型 A (endothelin receptor subtype A) 和内皮素受体亚型 B (endothelin receptor subtype B) 拮抗剂，pKi 值分别为 8.69、7.20。ATZ-1993 具有研究颈动脉球囊剥脱术后内膜增生的潜力。

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ATZ-1993 Chemical Structure

ATZ-1993 Chemical Structure

CAS No. : 219705-77-8

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ATZ-1993 相关抗体

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查看 Endothelin Receptor 亚型特异性产品:

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ETA ETB

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATZ-1993 is an orally active, nonpeptide endothelin receptor subtype Aand endothelin receptor subtype B antagonist with pKi values of 8.69, 7.20, respectively. ATZ-1993 has the potential for the research of intimal hyperplasia after balloon denudation of the carotid artery[1].

IC50 & Target[1]

ETA

8.69 (pKi)

ETB

7.20 (pKi)

体内研究
(In Vivo)

ATZ-1993 (30 mg/kg; drinking water, daily for 1 week) 可抑制球囊剥脱后的内膜增生[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Japanese White male rabbits[1]
Dosage: 30 mg/kg
Administration: Drinking water, daily for 1 weeks
Result: Inhibited the intimal hyperplasia with the inhibition rate approximately 77%, increased in intima:media ratio and DNA content.
分子量

484.55

Formula

C28H28N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATZ-1993 相关分类

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Keywords:

ATZ-1993219705-77-8ATZ1993ATZ 1993Endothelin Receptorcarotid artery balloon denudationorally activeintimal hyperplasiaInhibitorinhibitorinhibit

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