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  3. AUY 954 hydrochloride

AUY 954 hydrochloride是一种强效且选择性的鞘氨醇-1-磷酸 (S1P(1)) 受体激动剂,具有显著的免疫调节活性。AUY 954 hydrochloride口服后可诱导循环淋巴细胞显著且可逆性减少。AUY 954 hydrochloride在严格的移植模型中与 RAD001 联合使用时,已证明可延长心脏移植存活期。AUY 954 hydrochloride可有效预防大鼠实验性自身免疫性神经炎,展现出其在自身免疫性疾病中的抑制潜力。

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AUY 954 hydrochloride Chemical Structure

AUY 954 hydrochloride Chemical Structure

CAS No. : 820240-78-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AUY 954 hydrochloride is a potent and selective sphingosine-1-phosphate (S1P(1)) receptor agonist, exhibiting significant immunomodulatory activity. AUY 954 hydrochloride induces a profound and reversible reduction of circulating lymphocytes upon oral administration. AUY 954 hydrochloride has demonstrated efficacy in prolonging cardiac allograft survival when used in combination with RAD001 in a stringent transplantation model. AUY 954 hydrochloride effectively prevents experimental autoimmune neuritis in rats, showcasing its therapeutic potential in autoimmune conditions.

分子量

491.95

Formula

C25H21ClF3NO2S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

AUY 954 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
AUY 954 hydrochloride
目录号:
HY-119221A
需求量: