2. GPCR/G Protein
  3. Guanylate Cyclase
  4. BAY 41-8543

BAY 41-8543 是口服有效的，不依赖一氧化氮 (NO) 的可溶性鸟苷酸环化酶 (sGC) 的刺激物。BAY 41-8543 在大鼠的肺和全身血管床中具有血管舒张活性。BAY 41-8543 具有抗血小板作用，并有用于心血管疾病研究的潜力。

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BAY 41-8543 Chemical Structure

BAY 41-8543 Chemical Structure

CAS No. : 256498-66-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMF ￥1100
In-stock
1 mg ￥502
In-stock
5 mg ￥1000
In-stock
10 mg ￥1600
In-stock
25 mg ￥3200
In-stock
50 mg ￥5120
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

BAY 41-8543 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BAY 41-8543 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research[1].

体内研究
(In Vivo)

BAY 41-8543 (10-100 μg/kg; IV) produces small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output[1].
BAY 41-8543 (0.003, 0.01, 0.03, 0.1, and 0.3 mg/kg; iv) produces a dose-dependent and long-lasting decrease in blood pressure in anaesthetized rats. The blood pressure lowering effect of BAY 41-8543 lasts longer than the observation period of 30 min. BAY 41-8543 (0.1, 0.3 and 1.0 mg kg; oral) has maximal blood pressure lowering effects. The blood pressure lowering effects of the highest doses of BAY41-8543 lasts longer than the observation period of 120 min[2].
BAY 41-8543 (3 mg/kg; p.o.; twice daily; for 5 weeks) completely prevents the development of the increase in systolic blood pressure in 18-week-old renin transgenic rats (TGR(mRen2)27) on L-NAME treatment. BAY 41-8543 dramatically increases survival[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats weighing 325-450 g[1]
Dosage: 10, 30, and 100 μg/kg
Administration: IV
Result: Produced small decreases in pulmonary arterial pressure, larger dose-dependent decreases in systemic arterial pressure, and increases in cardiac output.
分子量

420.44

Formula

C21H21FN8O
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMF 中的溶解度 : 16.67 mg/mL (39.65 mM; 超声助溶)

Ethanol 中的溶解度 : 1 mg/mL (2.38 mM; 超声助溶 (<70°C))

DMSO 中的溶解度 : < 1 mg/mL (insoluble or slightly soluble)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3785 mL 11.8923 mL 23.7846 mL
5 mM 0.4757 mL 2.3785 mL 4.7569 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

BAY 41-8543 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMF 1 mM 2.3785 mL 11.8923 mL 23.7846 mL 59.4615 mL
DMF 5 mM 0.4757 mL 2.3785 mL 4.7569 mL 11.8923 mL
10 mM 0.2378 mL 1.1892 mL 2.3785 mL 5.9462 mL
15 mM 0.1586 mL 0.7928 mL 1.5856 mL 3.9641 mL
20 mM 0.1189 mL 0.5946 mL 1.1892 mL 2.9731 mL
25 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3785 mL
30 mM 0.0793 mL 0.3964 mL 0.7928 mL 1.9821 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 41-8543256498-66-5Guanylate CyclaseorallynitricoxideNOsolublesGCvasodilatorpulmonarysystemicvascularbedsantiplateletcardiovascularInhibitorinhibitorinhibit

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产品名称：
BAY 41-8543
目录号：
HY-W062836
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