2. Apoptosis
  3. Apoptosis Caspase Bcl-2 Family
  4. BBR-BODIPY

BBR-BODIPY 是一种荧光探针 (fluorescent probe)，可以筛选其与靶细胞的相互作用。BBR-BODIPY 诱导细胞凋亡改变凋亡相关蛋白的表达。

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BBR-BODIPY Chemical Structure

BBR-BODIPY Chemical Structure

CAS No. : 2456476-47-2

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规格 价格 是否有货 数量
1 mg ￥1200
In-stock
5 mg ￥2760
In-stock
10 mg ￥4200
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

BBR-BODIPY 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins[1].

IC50 & Target

Bax

 

Caspase-9

 

体外研究
(In Vitro)

BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) has anti-proliferative activity[1].
BBR-BODIPY (2-16 μM; 5-60 mins; MCF7 cells) could be quickly taken up into MCF7 cells in 5 mins and the fluorescence intensity exhibits a time-dependent manner[1].
BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) accumulates in mitochondria and overlaps with Mito tracker red to display yellow fluorescence with a Pearsons co-localization coefficient of 0.72[1].
BBR-BODIPY (8 μM, 12 hours) induces apoptosis in MCF7 cells through a mitochondrial pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BBR-BODIPY 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MCF7 and MDA-MB-231 cells
Concentration: 1 , 2 , 4 , 8 , 16 and 32 μM
Incubation Time: 24 hours
Result: Inhibited with IC50 values of 40.81 and 41.46 μM for MCF7 and MDA-MB-231 cells, respectively.

Western Blot Analysis[1]

Cell Line: MCF7 cells
Concentration: 8 μM
Incubation Time: 12 hours
Result: The amounts of Bax and Cyto C released from mitochondria and cleaved Caspase 9 were up-regulated in MCF7 cells.
分子量

861.18

Formula

C47H48BClF2N6O5
CAS 号
性状

固体

颜色

Orange to red

Emission (Em)

563
Excitation (Ex)

535
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 62.5 mg/mL (72.57 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1612 mL 5.8060 mL 11.6120 mL
5 mM 0.2322 mL 1.1612 mL 2.3224 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

BBR-BODIPY 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1612 mL 5.8060 mL 11.6120 mL 29.0299 mL
5 mM 0.2322 mL 1.1612 mL 2.3224 mL 5.8060 mL
10 mM 0.1161 mL 0.5806 mL 1.1612 mL 2.9030 mL
15 mM 0.0774 mL 0.3871 mL 0.7741 mL 1.9353 mL
20 mM 0.0581 mL 0.2903 mL 0.5806 mL 1.4515 mL
25 mM 0.0464 mL 0.2322 mL 0.4645 mL 1.1612 mL
30 mM 0.0387 mL 0.1935 mL 0.3871 mL 0.9677 mL
40 mM 0.0290 mL 0.1451 mL 0.2903 mL 0.7257 mL
50 mM 0.0232 mL 0.1161 mL 0.2322 mL 0.5806 mL
60 mM 0.0194 mL 0.0968 mL 0.1935 mL 0.4838 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BBR-BODIPY2456476-47-2ApoptosisCaspaseBcl-2 Familyfluorescent probeanticancerapoptosisfluorescently labeled natural productInhibitorinhibitorinhibit

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目录号：
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