BChE/HDAC6-IN-2 

BChE/HDAC6-IN-2 (compound 29a) is a dual inhibitor of BChE and HDAC6 with IC50s of 1.8 nM and 71.0 nM, respectively. BChE/HDAC6-IN-2 has prominently neuroprotective effects and reactive oxygen species (ROS) scavenging activity. BChE/HDAC6-IN-2 is also an effective chelator of metal ion (Fe2+ and Cu2+). BChE/HDAC6-IN-2 inhibits phosphorylation of tau, and exhibits moderate immunomodulatory effect.

IC50: 1.8 nM (BChE), 71.0 nM (HDAC6)

BChE/HDAC6-IN-2 (compound 29a) (0.1 μM，1 μM；24 小时) 在 10 μM Aβ(1-42) 处理的 SH-SY5Y 细胞中增加 α-微管蛋白的乙酰化水平，抑制 tau 的磷酸化^[1]。
BChE/HDAC6-IN-2 (5 μM、10 μM、20 μM) 抑制 SH-SY5Y 细胞中谷氨酸诱导的损伤，显示出神经保护作用^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

474.55

C₂₇H₃₀N₄O₄

2925457-33-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Wang L, Sun T, Wang Z, Liu H, Qiu W, Tang X, Guo H, Yang P, Chen Y, Sun H. Design, Synthesis, and Proof of Concept of Balanced Dual Inhibitors of Butyrylcholinesterase (BChE) and Histone Deacetylase 6 (HDAC6) for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2023 Sep 6;14(17):3226-3248.  [Content Brief]