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  4. Berberrubine chloride

Berberrubine chloride  (Synonyms: 小檗红碱)

目录号: HY-125850 纯度: 99.28%
COA 产品使用指南 技术支持

Berberrubine chloride 是一种具有口服活性的小檗碱的活性代谢物。Berberrubine chloride 可缓解小鼠结肠炎模型中的粘膜损伤和炎症。Berberrubine chloride 具有抗炎、抗肿瘤和抗病毒的活性。

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Berberrubine chloride Chemical Structure

Berberrubine chloride Chemical Structure

CAS No. : 15401-69-1

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规格 价格 是否有货 数量
1 mg ￥171
In-stock
5 mg ￥350
In-stock
10 mg ￥520
In-stock
25 mg ￥950
In-stock
50 mg ￥1450
In-stock
100 mg ￥2150
In-stock
200 mg   询价  
500 mg   询价  

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Other Forms of Berberrubine chloride:

Berberrubine chloride 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Berberrubine chloride is an orally active metabolite of berberine. Berberrubine chloride alleviates mucosal lesions and inflammation in mouse colitis models. Berberrubine chloride has anti-inflammatory, anti-tumor, and antiviral activities[1][1][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Bel-7402 IC50
34.31 μM
Compound: 2, Berberrubine
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
Cytotoxicity against human Bel7402 cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
BGC-823 IC50
7.66 μM
Compound: 2, Berberrubine
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
Cytotoxicity against human BGC823 cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
CCRF-CEM CC50
169.2 μM
Compound: 5
Cytotoxicity against human CEM cells expressing green fluorescent protein after 48 hrs by MTT assay
Cytotoxicity against human CEM cells expressing green fluorescent protein after 48 hrs by MTT assay
[PMID: 21295891]
CCRF-CEM EC50
2.8 μM
Compound: 5
Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production measured 7 days post infection by ELISA
Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production measured 7 days post infection by ELISA
[PMID: 21295891]
HepG2 IC50
> 50 μM
Compound: 2, Berberrubine
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 24 hrs by MTT assay
[PMID: 23182088]
HepG2 IC50
> 50 μM
Compound: 2, Berberrubine
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 23182088]
HL-60 IC50
11.36 μM
Compound: 2, Berberrubine
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
HT-29 IC50
> 50 μM
Compound: 2, Berberrubine
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 24 hrs by MTT assay
[PMID: 23182088]
HT-29 IC50
36.93 μM
Compound: 2, Berberrubine
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
Cytotoxicity against human HT-29 cells after 48 hrs by MTT assay
[PMID: 23182088]
KB IC50
6.92 μM
Compound: 2, Berberrubine
Cytotoxicity against human KB cells after 48 hrs by MTT assay
Cytotoxicity against human KB cells after 48 hrs by MTT assay
10.1007/s00044-013-0796-9
体外研究
(In Vitro)

Berberrubine (48 小时) 对 HT-29 细胞具有抑制作用，IC50 为 36.93 μM[1]。
Berberrubine (7 天) 在 CEM-GFP 细胞中对 HIV-1 NL4.3 病毒的 EC50 为 2.8 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Berberrubine chloride 相关抗体:
体内研究
(In Vivo)

Berberrubine (口服; 10-20 mg/kg; 7 天) 在小鼠结肠炎模型中具有改善作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS (HY-116282) treated male Balb/c mice aged 6 weeks old[3]
Dosage: 10 and 20 mg/kg
Administration: Oral administration (p.o.); 7 days
Result: Significantly reduced the disease activity index (DAI) with prolonged colon length and increased bodyweight at dose of 20 mg/kg.
Significantly ameliorated the DSS-induced colonic pathological alternations and decreased histological scores.
Markedly attenuated colonic inflammation by alleviating inflammatory cell infiltration and inhibiting myeloperoxidase (MPO) and cytokines (TNF-α, IFN-γ, IL-1β, IL-6, IL-4 and IL-10) productions in DSS mice.
Substantially upregulated the expression of tight junction proteins (zonula occludens-1, zonula occludens-2, claudin-1, occludin) and mRNA expression of mucins (mucin-1 and mucin-2), and decreased the Bax/Bcl-2 ratio.
分子量

357.79

Formula

C19H16ClNO4
CAS 号
性状

固体

颜色

Yellow to reddish brown

中文名称

小檗红碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5 mg/mL (13.97 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

Ethanol 中的溶解度 : 2 mg/mL (5.59 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7949 mL 13.9747 mL 27.9494 mL
5 mM 0.5590 mL 2.7949 mL 5.5899 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： 0.5% CMC-Na/saline water

    Solubility: 5 mg/mL (13.97 mM); 悬浊液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.28%

COA (290 KB) HNMR (253 KB) RP-HPLC (263 KB) MS (70 KB)

产品使用指南 (1538 KB)
参考文献

Berberrubine chloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.7949 mL 13.9747 mL 27.9494 mL 69.8734 mL
5 mM 0.5590 mL 2.7949 mL 5.5899 mL 13.9747 mL
DMSO 10 mM 0.2795 mL 1.3975 mL 2.7949 mL 6.9873 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Berberrubine15401-69-1小檗红碱Drug MetaboliteHIVInterleukin RelatedHuman immunodeficiency virusILcolitis modelsHT-29CEM-GFPInhibitorinhibitorinhibit

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