2. Epigenetics
  3. Histone Methyltransferase
  4. Bisegliptin

Bisegliptin  (Synonyms: KRP-104)

目录号: HY-121029
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摩尔计算器

Bisegliptin (KRP-104)是一种小分子化合物，具有抗糖尿病活性。Bisegliptin的代谢主要通过将氰基转化为羧酸形式进行，且DPP-4在其代谢中起到部分作用。Bisegliptin的羧酸代谢物在体内和体外均可被检测到。Bisegliptin在大鼠实验中，其羧酸代谢物的血浆浓度受到其他DPP抑制剂的影响，显示了其代谢过程的复杂性。Bisegliptin的酰胺中间体在体内外均被检测到，并且在与DPP-4孵育时，其转化速度显著快于母体化合物。

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Bisegliptin Chemical Structure

Bisegliptin Chemical Structure

CAS No. : 862501-61-9

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Bisegliptin 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bisegliptin (KRP-104) is a small molecule compound with antidiabetic activity. Bisegliptin is metabolized mainly by converting the cyano group to the carboxylic acid form, and DPP-4 plays a partial role in its metabolism. The carboxylic acid metabolite of bisegliptin can be detected both in vivo and in vitro. In rat experiments, the plasma concentration of the carboxylic acid metabolite of bisegliptin was affected by other DPP inhibitors, showing the complexity of its metabolic process. The amide intermediate of bisegliptin was detected both in vivo and in vitro, and its conversion rate was significantly faster than that of the parent compound when incubated with DPP-4[1].

分子量

351.42

Formula

C18H26FN3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bisegliptin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bisegliptin862501-61-9KRP-104KRP104KRP 104Histone MethyltransferaseInhibitorinhibitorinhibit

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