2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor 5-HT Receptor
  4. BMY 7378 free base

BMY 7378 (free base) 是 α1D 肾上腺素受体 (α1D-AR) 的选择性拮抗剂。BMY 7378 (free base) 对表达克隆大鼠 α1D-AR 的膜结合的亲和力 (Ki=2 nM) 比对克隆大鼠 α1A-AR (Ki=800 nM) 或仓鼠 α1B-AR (Ki=600 nM) 结合的亲和力强超过 100 倍。BMY 7378 (free base) 是一种 5-HT1A 受体部分激动剂。

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BMY 7378 free base Chemical Structure

BMY 7378 free base Chemical Structure

CAS No. : 21102-94-3

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BMY 7378 free base 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMY 7378 (free base) is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 (free base) binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 (free base) is a 5-HT1A receptor partial agonist[1][2].

分子量

385.50

Formula

C22H31N3O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BMY 7378 free base 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMY 737821102-94-3BMY7378BMY-7378Adrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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