2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. BRL-44408

BRL-44408 是一种选择性的肾上腺素能受体 α2A/α2B AR 的拮抗剂。BRL-44408 能有效拮抗去甲肾上腺素或肾上腺素受体激动剂 Clonidine (HY-12721) 对 K+ 诱导的 [3H]去甲肾上腺素和[3H]5-羟色胺释放的抑制作用。BRL-44408 与含有 α2A-肾上腺素受体的人血小板膜的亲和力，比 BRL-41992 和 Imiloxan (HY-101337) 更高。BRL-44408 可能通过调节 α2A-肾上腺素受体介导的机制影响去甲肾上腺素和 5-羟色胺的释放，在神经递质释放调节中具有潜在作用。

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BRL-44408 Chemical Structure

BRL-44408 Chemical Structure

CAS No. : 118343-19-4

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BRL-44408 的其他形式现货产品:

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BRL-44408 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRL-44408 is a selective adrenergic receptor antagonist of α2A/α2B AR. BRL-44408 can effectively antagonize the inhibitory effects of norepinephrine or adrenergic receptor agonist Clonidine (HY-12721) on K+-induced [3H]norepinephrine and [3H]5-hydroxytryptamine release. BRL-44408 has a higher affinity for human platelet membranes containing α2A-adrenoceptors than BRL-41992 and Imiloxan (HY-101337). BRL-44408 may affect the release of norepinephrine and 5-hydroxytryptamine through a mechanism mediated by α2A-adrenoceptors, and has a potential role in the regulation of neurotransmitter release[1].

分子量

215.29

Formula

C13H17N3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRL-44408 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRL-44408118343-19-4BRL44408BRL 44408Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-12716
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