2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Bz-FVR-AMC

Bz-FVR-AMC 是一种组织蛋白酶荧光底物，kcat/Km 值为 1070 mM-1s-1。高浓度 BZ-FVR-AMC 对底物有抑制作用。

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Bz-FVR-AMC Chemical Structure

Bz-FVR-AMC Chemical Structure

CAS No. : 88899-22-3

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规格 价格 是否有货 数量
5 mg ￥625
In-stock
10 mg ￥944
In-stock
25 mg ￥1700
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Bz-FVR-AMC:

Bz-FVR-AMC 相关抗体

Top Publications Citing Use of Products

查看 Cathepsin 亚型特异性产品:

查看所有亚型
Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bz-FVR-AMC is a fluorogenic substrate for procathepsin with a kcat/Km value of 1070 mM-1s-1. The high concentration of BZ-FVR-AMC inhibits the substrate[1][2].

体外研究
(In Vitro)

Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
Processing and activation of procathepsin S[2]:
1. Autocatalytic activation of procathepsin S was studied by incubation (final concentration 1-5 μM) at 37 ℃ in 0.5 mL of the appropriate buffer containing 2.5 mM dithiothreitol.
2. Aliquots of 10 μl were taken from the reaction mixture at the times indicated and mixed with 2.5 ml of substrate solution (10 μM Bz-FVR-AMC in 0.1 M phosphate buffer, pH 6.5, containing 1 mM EDTA (HY-Y0682) and 0.1% (w/v) polyethylene glycol 6000).
3. Fluorescence of the released AMC was then monitored continuously for 1 min in a pectrofluorimeter at excitation and emission wavelengths of 370 and 460 nm.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bz-FVR-AMC 相关抗体:
分子量

681.78

Formula

C37H43N7O6
CAS 号
性状

固体

颜色

White to off-white

Emission (Em)

454
Excitation (Ex)

344
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 125 mg/mL (183.34 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4667 mL 7.3337 mL 14.6675 mL
5 mM 0.2933 mL 1.4667 mL 2.9335 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Bz-FVR-AMC 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4667 mL 7.3337 mL 14.6675 mL 36.6687 mL
5 mM 0.2933 mL 1.4667 mL 2.9335 mL 7.3337 mL
10 mM 0.1467 mL 0.7334 mL 1.4667 mL 3.6669 mL
15 mM 0.0978 mL 0.4889 mL 0.9778 mL 2.4446 mL
20 mM 0.0733 mL 0.3667 mL 0.7334 mL 1.8334 mL
25 mM 0.0587 mL 0.2933 mL 0.5867 mL 1.4667 mL
30 mM 0.0489 mL 0.2445 mL 0.4889 mL 1.2223 mL
40 mM 0.0367 mL 0.1833 mL 0.3667 mL 0.9167 mL
50 mM 0.0293 mL 0.1467 mL 0.2933 mL 0.7334 mL
60 mM 0.0244 mL 0.1222 mL 0.2445 mL 0.6111 mL
80 mM 0.0183 mL 0.0917 mL 0.1833 mL 0.4584 mL
100 mM 0.0147 mL 0.0733 mL 0.1467 mL 0.3667 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bz-FVR-AMC88899-22-3CathepsinInhibitorinhibitorinhibit

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产品名称：
Bz-FVR-AMC
目录号：
HY-D1634
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