2. Apoptosis Immunology/Inflammation
  3. Caspase Apoptosis Cyclophilin
  4. C105SR

C105SR 是一种以肽基脯氨酰反式异构酶 (PPIase) 为靶点的亲环素 D (CypD) 抑制剂，C105SR 抑制线粒体通透性转换开放 (mPTP) 的 IC 50 为 5 nM，C105SR 抑制缺氧复氧诱导的肝细胞凋亡，增加钙驻留能力 (CRC) 水平。C105SR 在缺血-再灌注损伤 (IRI) 小鼠模型中表现出肝脏保护作用。

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C105SR Chemical Structure

C105SR Chemical Structure

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Customer Review

C105SR 相关抗体

Top Publications Citing Use of Products

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Cyclophilin 亚型特异性产品:

查看所有亚型
Cyclophilin A Cyclophilin B Cyclophilin C Cyclophilin D Cyclophilin G Cyclophilin E

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model[1].

IC50 & Target[1]

Caspase 3

 

Caspase-7

 

Cyclophilin D

5 nM (IC50)

体外研究
(In Vitro)

C105SR (0.5/1/5/10/50/100 μM) 抑制线粒体 CypD PPIase 活性[1]。
C105SR (1μM, 4 h for hypoxia (1% O2) plus 1 h for reoxygenation (21% O2)) 可阻止 mPTP 开放[1]。
C105SR (0.5/1/5/10/50/100 μM, 4 h for hypoxia (1% O2) 减少了缺氧/复氧诱导的 AML-12 细胞死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C105SR 相关抗体:

Cell Viability Assay[1]

Cell Line: AML-12 cell
Concentration: 0.5/1/10/50/100 μM
Incubation Time: 4 h for hypoxia (1% O2) plus 2 h for reoxygenation (21% O2)
Result: Reduced LDH release and increased cell viability by approximatively 75% at 0.5μM.
体内研究
(In Vivo)

C105SR (50 mg/kg, Subcutaneous injection (s.c.), 24 h before ischaemia–reperfusion injury (IRI) surgical procedure, single dose) 在肝脏缺血再灌注损伤小鼠模型中有保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Hepatic IRI model [1]
Dosage: 50 mg/kg
Administration: Subcutaneous injection (s.c.)
Result: Protected mouse livers against the effects of ischaemia and reperfusion.
分子量

633.60

Formula

C32H33BrN4O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

C105SR 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C105SRCaspaseApoptosisCyclophilincyclophilin D inhibitorhepatocyte cell lineAML-12ischaemia-reperfusion injuryhypoxia and reoxygenationInhibitorinhibitorinhibit

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目录号：
HY-157088
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