1. 天然产物
  2. 植物 萜类
  3. 瑞香科 三萜
  4. Gyrinops walla Gaertn.
  5. 41552-82-3

41552-82-3

N6-Cyclopentyladenosine Chemical Structure

Chemical Structure

41552-82-3

  • N6-Cyclopentyladenosine
  • Synonym(s): CPA; UK-80882
  • CAS No.:41552-82-3
  • Formula:C15H21N5O4
  • Molecular Weight:335.36

生物活性:N6-Cyclopentyladenosine (CPA) 是一个选择性的腺苷 A1 受体 (Adenosine A1 receptor) 激动剂,其对人A1、A2A 和 A3 受体的 Ki 分别为 2.3 nM、790 nM 和 43 nM。N6-cyclopentyladenosine 增加凋亡 (Apoptosis)。N6-Cyclopentyladenosine 对白血病具有抗肿瘤作用。N6-cyclopentyladenosine 可改善 5-fluorouracil (HY-90006) 引起的造血损伤、调节睡眠并延缓 Aminophylline 引起的阵挛性癫痫发作。

N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures[1][2][3][4][5][6][7][8][9].

Cat. No. 产品名称 纯度 描述 价格
HY-103181 N6-Cyclopentyladenosine 99.59% N6-Cyclopentyladenosine (CPA) 是一个选择性的腺苷 A1 受体 (Adenosine A1 receptor) 激动剂,其对人A1、A2A 和 A3 受体的 Ki 分别为 2.3 nM、790 nM 和 43 nM。N6-cyclopentyladenosine 增加凋亡 (Apoptosis)。N6-Cyclopentyladenosine 对白血病具有抗肿瘤作用。N6-cyclopentyladenosine 可改善 5-fluorouracil (HY-90006) 引起的造血损伤、调节睡眠并延缓 Aminophylline 引起的阵挛性癫痫发作。

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规格 价格 是否有货 数量 操作
10 mM * 1mL

¥400.00

In-stock
5 mg

¥362.00

In-stock
10 mg

¥543.00

In-stock
50 mg

¥1100.00

In-stock
100 mg

¥2000.00

In-stock

References

[1]. Klotz KN, et al. Adenosine receptors and their ligands. Naunyn Schmiedebergs Arch Pharmacol. 2000 Nov;362(4-5):382-91. [Content Brief]
[2]. Soliño M, et al. Adenosine A1 receptor: A neuroprotective target in light induced retinal degeneration. PLoS One. 2018 Jun 18;13(6):e0198838. [Content Brief]
[3]. Mlejnek P, et al. Apoptosis induced by N6-substituted derivatives of adenosine is related to intracellular accumulation of corresponding mononucleotides in HL-60 cells. Toxicol In Vitro. 2005 Oct;19(7):985-90. [Content Brief]
[4]. Pospísil M, et al. N6-cyclopentyladenosine inhibits proliferation of murine haematopoietic progenitor cells in vivo. Eur J Pharmacol. 2005 Jan 10;507(1-3):1-6. [Content Brief]
[5]. Schwierin B, et al. Effects of N6-cyclopentyladenosine and caffeine on sleep regulation in the rat. Eur J Pharmacol. 1996 Apr 11;300(3):163-71. [Content Brief]
[6]. Normile HJ, et al. N6-cyclopentyladenosine impairs passive avoidance retention by selective action at A1 receptors. Brain Res Bull. 1991 Jul;27(1):101-4. [Content Brief]
[7]. Mathôt RA, et al. Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat. J Pharmacol Exp Ther. 1994 Feb;268(2):616-24. [Content Brief]
[8]. Mathôt RA, et al. Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo. Br J Pharmacol. 1995 Oct;116(3):1957-64. [Content Brief]
[9]. Jaishree J, et al. Individual and combined effects of N6-cyclopentyladenosine, flunarizine and diazepam on aminophylline-induced recurrent generalized seizures in mice. Pol J Pharmacol. 2003 Jul-Aug;55(4):559-64. [Content Brief]

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