2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. Cemiplimab

Cemiplimab  (Synonyms: 西米普利单抗)

目录号: HY-P99203 纯度: 99.89%
COA

摩尔计算器

Cemiplimab (Anti-Human PD-1) 是一种具有高亲和力的程序性死亡受体-1 (PD-1) 单克隆 IgG4 抗体，可阻断 PD-1/PD-L1 介导的 T 细胞抑制。常用于鳞状细胞皮肤癌研究。

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CAS No. : 1801342-60-8

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规格 价格 是否有货 数量
1 mg ￥1800
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5 mg ￥5400
In-stock
10 mg ￥8650
In-stock
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Cemiplimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cemiplimab (Anti-Human PD-1) is a high-affinity programmed death receptor-1 (PD-1) monoclonal IgG4 antibody that blocks PD-1/PD-L1-mediated T-cell suppression. Cemiplimab is commonly used in squamous cell skin cancer research[1][2].

同型

Human IgG4 kappa
推荐同型对照抗体
种属

Human
体内研究
(In Vivo)

Cemiplimab (i.p., 10 mg/kg, five injections within 2 weeks) can increased the proportion of effector T cells in tumors and dLNs to reduce tumor growth by combined immunotherapy with REGN3767 in MC38.Ova tumor mice model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female human PD-1×LAG-3 knockin mice (8-10 weeks) with MC38.Ova cells[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; five injections within 2 weeks
Result: Partially inhibited the growth of MC38.Ova tumors and prolonged the survival of mice by administering alone.
Significantly increased the proportion of CD4+ TILs in IFNγ and TNFα by combined immunotherapy with REGN3767.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

西米普利单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized Human PD-1 Protein (ECD, His Tag) can bind Cemiplimab. The EC50 for this effect is 1.73 ng/mL.
纯度 & 产品资料
参考文献

Cemiplimab 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cemiplimab1801342-60-8西米普利单抗PD-1/PD-L1PD-1/Programmed death-ligand 1monoclonal IgG4 antibodyprogrammed death receptor-1PD-1T-cellcancersquamous cell skin cancerInhibitorinhibitorinhibit

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