2. Cell Cycle/DNA Damage Epigenetics Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Stem Cell/Wnt JAK/STAT Signaling
  3. Aurora Kinase Bcr-Abl Akt STAT FLT3
  4. Cenisertib benzoate

Cenisertib benzoate  (Synonyms: AS-703569 benzoate; R-763 benzoate)

目录号: HY-13072B
产品使用指南

摩尔计算器

Cenisertib (AS-703569) benzoate 是一种 ATP 竞争性的多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。Cenisertib benzoate 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。Cenisertib benzoate 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。

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Cenisertib benzoate Chemical Structure

Cenisertib benzoate Chemical Structure

CAS No. : 1145859-64-8

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Cenisertib benzoate 的其他形式现货产品:

Other Forms of Cenisertib benzoate:

Cenisertib benzoate 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Aurora Kinase 亚型特异性产品:

查看所有亚型
Aurora Kinase Aurora A Aurora B Aurora C

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Cenisertib (AS-703569) benzoate is an ATP-competitive multi-kinase inhibitor that blocks the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5 and FLT3. Cenisertib benzoate induces major growth-inhibitory effects by blocking the activity of several different molecular targets in neoplastic mast cells (MC). Cenisertib benzoate inhibits tumor growth in xenograft models of pancreatic, breast, colon, ovarian, and lung tumors and leukemia[1][2][3].

分子量

573.66

Formula

C31H36FN7O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Cenisertib benzoate 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cenisertib1145859-64-8AS-703569R-763AS703569AS 703569R763R 763Aurora KinaseBcr-AblAktSTATFLT3PKBProtein kinase BCluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Inhibitorinhibitorinhibit

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