2. Protein Tyrosine Kinase/RTK JAK/STAT Signaling Apoptosis
  3. VEGFR EGFR RET Apoptosis
  4. CLM3

CLM3 是一种吡唑并嘧啶衍生物，是一种多酪氨酸激酶抑制剂。CLM3 对内皮细胞和癌细胞具有抗增殖和促凋亡活性，SN38 (HY-13704) 可协同增强这种活性。这些作用主要是由于 CLM3 抑制了 VEGFR-2、EGFR 和 RET 酪氨酸激酶及其相关信号通路的磷酸化。

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CLM3 Chemical Structure

CLM3 Chemical Structure

CAS No. : 1312024-59-1

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CLM3 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

查看所有亚型
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

查看 EGFR 亚型特异性产品:

查看所有亚型
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CLM3, a pyrazolopyrimidine derivative, is a multiple tyrosine kinase inhibitor. CLM3 shows antiproliferative and proapoptotic activity on endothelial and cancer cells, synergistically enhanced by SN38 (HY-13704). These effects are mainly due to its inhibition of phosphorylation of VEGFR-2, EGFR and RET tyrosine kinases and their related signaling pathways[1].

IC50 & Target

VEGFR2

 

体外研究
(In Vitro)

CLM3 (0-100 μM, 72 h) 显著降低活化内皮细胞和癌细胞中磷酸化 VEGFR-2、磷酸化 EGFR 和磷酸化 RET 的水平[1]。
CLM3 (0-100 μM, 72 h) 显著抑制内皮细胞和癌细胞中细胞周期蛋白 D1 基因的表达，降低细胞周期蛋白 D1 蛋白的细胞内浓度[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CLM3 相关抗体:
分子量

343.42

Formula

C21H21N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CLM3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CLM31312024-59-1CLM 3CLM-3VEGFREGFRRETApoptosisVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1HMVEC-dA5498305C cellscyclin D1endothelialcancer cellsInhibitorinhibitorinhibit

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目录号：
HY-164413
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