Clovibactin TFA 

Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors^[1].

Clovibactin TFA 对葡萄球菌菌株具有抑制活性，MIC 为 0.125-2 μg/mL^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clovibactin TFA (20 mg/kg，静脉注射，单剂量) 在 CD-1 小鼠模型内的药代动力学特征为 C_max 为 219.3 μg/mL，AUC_{to last} 为 31.9 μg·h/mL，t_1/2 为 2 h，CL 为 9.4 mL/kg/min 以及 V_dss 为 189.8 mL/kg^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

903.08 (free base)

C₄₃H₇₀N₁₀O₁₁.xC₂HF₃O₂

固体

White to off-white

Phe-{d-Leu}-{d-Lys}-Ser-{Hyn}-Ala-Leu-Leu (Cyclic ester: Hyn5-Leu8)

F-{d-Leu}-{d-Lys}-S-{Hyn}-ALL (Cyclic ester: Hyn5-Leu8)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Shukla R, et al., A new antibiotic from an uncultured bacterium binds to an immutable target. bioRxiv [Preprint]. 2023 May 15:2023.05.15.540765.  [Content Brief]