2. Metabolic Enzyme/Protease
  3. CETP
  4. CP-532623

CP-532623 是 CETP 抑制剂，可提高高密度脂蛋白胆固醇水平。CP-532623 与 Torcetrapib 的结构相似，并具有高度亲脂性。

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CP-532623 Chemical Structure

CP-532623 Chemical Structure

CAS No. : 261947-38-0

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3.  试用装只面向终端客户。

规格 价格 是否有货
5 mg ￥2160
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Customer Review

CP-532623 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CP-532623 is a CETP inhibitor and elevates high-density lipoprotein cholesterolion. CP-532623 is a close structural analogue of Torcetrapib. CP-532623 has highly lipophilic properties[1][2][3].

IC50 & Target

CETP[1]
体外研究
(In Vitro)

CP-532623 is highly lymphatically transported (28% of dose), and lymphatic transport is closely correlated with drug affinity for ex-vivo lymph lipoproteins or triglyceride emulsions and poorly relates to solubility in mixtures of lipoprotein core and/or surface lipids. CP-532623 alters the kinetics of lymph lipid transport and decreases lymph lipid transport in chylomicrons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CP-532623 相关抗体:
体内研究
(In Vivo)

CP-532623 (50 mg; oral administration; adult male greyhound dogs) treatment substantially transports into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhances oral bioavailability (from 44 to 58%, respectively) and the proportion of the absorbed dose transports via the lymph (from 61 to 86% and from 68 to 83%, respectively). Lymphatic triglyceride transport is significantly lower in fed dogs administered CP-532623[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male greyhound dogs (27-39 kg)[3]
Dosage: 50 mg
Administration: Oral administration with a long-chain lipid formulation to fed lymphcannulated
Result: Substantially transported into the lymphatic system (>25% dose) in fed and fasted dogs. Food enhanced oral bioavailability and the proportion of the absorbed dose transported via the lymph.
分子量

598.50

Formula

C27H27F9N2O3
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 20 mg/mL (33.42 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.6708 mL 8.3542 mL 16.7084 mL
5 mM 0.3342 mL 1.6708 mL 3.3417 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (174 KB)

产品使用指南 (1538 KB)
参考文献

CP-532623 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6708 mL 8.3542 mL 16.7084 mL 41.7711 mL
5 mM 0.3342 mL 1.6708 mL 3.3417 mL 8.3542 mL
10 mM 0.1671 mL 0.8354 mL 1.6708 mL 4.1771 mL
15 mM 0.1114 mL 0.5569 mL 1.1139 mL 2.7847 mL
20 mM 0.0835 mL 0.4177 mL 0.8354 mL 2.0886 mL
25 mM 0.0668 mL 0.3342 mL 0.6683 mL 1.6708 mL
30 mM 0.0557 mL 0.2785 mL 0.5569 mL 1.3924 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-532623261947-38-0CP532623CP 532623CETPCholesteryl ester transfer proteinLymphaticallylipoproteinstriglyceridelipophilicHDL-CTorcetrapiboralbioavailabilityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-123039
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