Crocetin (Synonyms: 藏红花酸; Transcrocetin; trans-Crocetin)

目录号: HY-N2072 纯度: 98.22%: FAQs
Data Sheet SDS COA 产品使用指南技术支持

Crocetin (Transcrocetin) 从藏红花 (Crocus sativus L.) 中提取的，是一种可透过血脑屏障的，高亲和力的 NMDA 受体拮抗剂。

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Crocetin Chemical Structure

CAS No. : 27876-94-4

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规格	价格	是否有货
1 mg	￥516	In-stock
5 mg	￥1200	In-stock
10 mg	￥1800	In-stock
25 mg	￥3163	In-stock
50 mg	￥4650	In-stock
100 mg	现货	询价
500 mg	现货	询价
1 g		询价
5 g		询价

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Other Forms of Crocetin:

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AMPA Receptor NMDA Receptor Kainate Receptor

生物活性
实验参考方法
纯度 & 产品资料
参考文献

生物活性

Crocetin (Transcrocetin), extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity^[1]. Crocetin is capable of crossing the blood-brain barrier and reach the central nervous system (CNS)^[2].

IC₅₀ & Target

NMDA Receptor

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	5.99 μM Compound: 18	Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method	[PMID: 23305920]

体外研究
(In Vitro)

Crocetin 是一种源自藏红花素类胡萝卜素的藏红花代谢物，已被证明具有很强的 NMDA 受体亲和力，被认为与Crocetin 的中枢神经系统活性有关。10 μM 的 Crocetin 不会改变细胞活力，而较高浓度 (40-160 μM) 会显著降低细胞活力^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

328.40

Formula

C₂₀H₂₄O₄

CAS 号

27876-94-4

性状

固体

颜色

Yellow to orange

中文名称

藏红花酸；西红花酸；番红花酸

结构分类

初始来源

内源性代谢物

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years

*该产品在溶液状态不稳定，建议您现用现配，即刻使用。

溶解性数据

细胞实验：

DMSO 中的溶解度 : 20 mg/mL (60.90 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0451 mL	15.2253 mL	30.4507 mL
5 mM	0.6090 mL	3.0451 mL	6.0901 mL
10 mM	0.3045 mL	1.5225 mL	3.0451 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.22%

选择批次：

Data Sheet (605 KB) SDS (393 KB)

COA (282 KB) HNMR (257 KB) RP-HPLC (278 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44. [Content Brief]

[2]. José Bagur M, et al. Saffron: An Old Medicinal Plant and a Potential Novel Functional Food. Molecules. 2017 Dec 23;23(1). pii: E30. [Content Brief]

Cell Assay ^[1]	Cytotoxicity of test compounds is determined by MTT assay using Caco-2 cells in 96 well plates at a density of 20.000 cells per well in 200 µl FBS-free medium, grown for 96 h and followed by 24 h contact time with the test compounds (100 µL of serum-free media containing SE 0.5, 1, and 2 mg/mL; trans-crocin-1 250, 500, and 1000 µM; Transcrocetin 10, 40, 80, and 160 µM) and incubation at 37°C/5% CO₂. The incubation solutions are aspirated, each well is washed twice with 150 µL of PBS and 50 µL of MTT solution are added (2.5 mg/mL in PBS). Supernatants are discarded and the formed formazan is dissolved in 50 µL of DMSO. The absorption of the resulting solution is determined at λ=492 nm against reference wavelength λ=690 nm^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44. [Content Brief] [2]. José Bagur M, et al. Saffron: An Old Medicinal Plant and a Potential Novel Functional Food. Molecules. 2017 Dec 23;23(1). pii: E30. [Content Brief]

Cell Assay
^[1]

Cytotoxicity of test compounds is determined by MTT assay using Caco-2 cells in 96 well plates at a density of 20.000 cells per well in 200 µl FBS-free medium, grown for 96 h and followed by 24 h contact time with the test compounds (100 µL of serum-free media containing SE 0.5, 1, and 2 mg/mL; trans-crocin-1 250, 500, and 1000 µM; Transcrocetin 10, 40, 80, and 160 µM) and incubation at 37°C/5% CO₂. The incubation solutions are aspirated, each well is washed twice with 150 µL of PBS and 50 µL of MTT solution are added (2.5 mg/mL in PBS). Supernatants are discarded and the formed formazan is dissolved in 50 µL of DMSO. The absorption of the resulting solution is determined at λ=492 nm against reference wavelength λ=690 nm^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Lautenschläger M, et al. Intestinal formation of trans-Crocetin from saffron extract (Crocus sativus L.) and in vitro permeation through intestinal and blood brain barrier. Phytomedicine. 2015 Jan 15;22(1):36-44. [Content Brief]

[2]. José Bagur M, et al. Saffron: An Old Medicinal Plant and a Potential Novel Functional Food. Molecules. 2017 Dec 23;23(1). pii: E30. [Content Brief]

Crocetin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0451 mL	15.2253 mL	30.4507 mL	76.1267 mL
	5 mM	0.6090 mL	3.0451 mL	6.0901 mL	15.2253 mL
	10 mM	0.3045 mL	1.5225 mL	3.0451 mL	7.6127 mL
	15 mM	0.2030 mL	1.0150 mL	2.0300 mL	5.0751 mL
	20 mM	0.1523 mL	0.7613 mL	1.5225 mL	3.8063 mL
	25 mM	0.1218 mL	0.6090 mL	1.2180 mL	3.0451 mL
	30 mM	0.1015 mL	0.5075 mL	1.0150 mL	2.5376 mL
	40 mM	0.0761 mL	0.3806 mL	0.7613 mL	1.9032 mL
	50 mM	0.0609 mL	0.3045 mL	0.6090 mL	1.5225 mL
	60 mM	0.0508 mL	0.2538 mL	0.5075 mL	1.2688 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crocetin27876-94-4Transcrocetin trans-Crocetin藏红花酸西红花酸番红花酸iGluREndogenous MetaboliteIonotropic glutamate receptorsInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Crocetin (Synonyms: 藏红花酸; Transcrocetin; trans-Crocetin)

Customer Review

Other Forms of Crocetin: