Cyclo(Arg-Gly-Asp-D-Phe-Val) (Synonyms: Cyclo(RGDfV); C(RGDfV))

目录号: HY-P1613: FAQs
Data Sheet 产品使用指南技术支持

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) 是一种整合素 αvβ3 抑制剂。Cyclo(Arg-Gly-Asp-D-Phe-Val) 具有抗肿瘤活性。Cyclo(Arg-Gly-Asp-D-Phe-Val) 可用于急性髓系白血病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Cyclo(Arg-Gly-Asp-D-Phe-Val) Chemical Structure

CAS No. : 137813-35-5

1. 客户无需承担相应的运输费用。

2. 同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

可免费申领三个不同产品的试用装。

3. 试用装只面向终端客户。

规格		是否有货
50 mg		询价
100 mg		询价
250 mg		询价

or 大包装询价

* Please select Quantity before adding items.

Cyclo(Arg-Gly-Asp-D-Phe-Val) 的其他形式现货产品:

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA

Customer Review

Other Forms of Cyclo(Arg-Gly-Asp-D-Phe-Val):

Cyclo(Arg-Gly-Asp-D-Phe-Val) TFA In-stock

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 Integrin 亚型特异性产品:

查看所有亚型

αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

生物活性
纯度 & 产品资料
参考文献

生物活性

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Cyclo(RGDfV)) is an integrin αvβ3 inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) can be used for the research of acute myeloid leukemia^[1].

IC₅₀ & Target

αvβ3^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.25 x 10^-1 μM Compound: 6, c(RGDfV)	Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay Displacement of [125I]echistatin from human integrin alpha5beta3 expressed in human A549 cells by binding assay	[PMID: 21349709]
HUVEC	IC₅₀	0.53 μM Compound: CycloRGDfV	Inhibition of HUVEC migration after 4 hrs Inhibition of HUVEC migration after 4 hrs	[PMID: 19081719]
HUVEC	IC₅₀	3.1 μM Compound: CycloRGDfV	Inhibition of FGF-induced HUVEC proliferation after 48 hrs Inhibition of FGF-induced HUVEC proliferation after 48 hrs	[PMID: 19081719]
HUVEC	IC₅₀	4.5 μM Compound: CycloRGDfV	Inhibition of VEGF-induced HUVEC proliferation after 48 hrs Inhibition of VEGF-induced HUVEC proliferation after 48 hrs	[PMID: 19081719]
HUVEC	IC₅₀	9.6 μM Compound: c[RGDfV]	Inhibition of alphavbeta3 integrin-mediated cell adhesion in HUVEC on vitronectin coated plate after 30 mins Inhibition of alphavbeta3 integrin-mediated cell adhesion in HUVEC on vitronectin coated plate after 30 mins	[PMID: 20055426]
K562	IC₅₀	34.7 μM Compound: cyclo-Arg-Gly-Asp-D-Phe-Val	Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay Antagonist activity at alpha5beta1 integrin in human K562 cells assessed as inhibition of fibronectin-mediated cell adhesion after 30 mins by fluorescence assay	[PMID: 24973662]
K562	IC₅₀	34.7 μM Compound: c[RGDfV]	Inhibition of alpha5beta1 integrin-mediated cell adhesion in human K562 cells on fibronectin coated plate after 30 mins Inhibition of alpha5beta1 integrin-mediated cell adhesion in human K562 cells on fibronectin coated plate after 30 mins	[PMID: 20055426]
WM-115	IC₅₀	0.5 μM Compound: c-(-Arg-Gly-Asp-D-Phe-Val-)	Binding affinity to integrin in human WM-115 cells after 30 mins by immobilized vitronectin-based competitive cell adhesion assay Binding affinity to integrin in human WM-115 cells after 30 mins by immobilized vitronectin-based competitive cell adhesion assay	[PMID: 23387527]

体外研究
(In Vitro)

Cyclo(Arg-Gly-Asp-d-Phe-Val) (Cyclo(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cycle Analysis^[1]

Cell Line:	MV4–11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems.

Apoptosis Analysis^[1]

Cell Line:	MV4–11 cells
Concentration:	35 nM
Incubation Time:	24 h
Result:	Increased the apoptosis rates.

分子量

574.63

Formula

C₂₆H₃₈N₈O₇

CAS 号

137813-35-5

Sequence Shortening

Cyclo(RGD-{d-Phe}-V)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Shen ZH, et al. Targeting of the leukemia microenvironment by c(RGDfV) overcomes the resistance to chemotherapy in acute myeloid leukemia in biomimetic polystyrene scaffolds. Oncol Lett. 2016 Nov;12(5):3278-3284. [Content Brief]

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关分类

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclo(Arg-Gly-Asp-D-Phe-Val)137813-35-5Cyclo(RGDfV) C(RGDfV)IntegrinApoptosisintegrin αvβ3antitumoracute myeloid leukemiacancerInhibitorinhibitorinhibit

您最近查看的产品:

产品名称：

* 需求量：

* 客户姓名：

* Email：

* 电话：

* 公司或机构名称：

留言给我们：

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Synonyms: Cyclo(RGDfV); C(RGDfV))

Customer Review

Other Forms of Cyclo(Arg-Gly-Asp-D-Phe-Val):

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 Integrin 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

产品名称：			* Lot #：
* 客户姓名：			* Email：
电话：			* 部门：
* 公司或机构名称：
留言给我们：

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

Cyclo(Arg-Gly-Asp-D-Phe-Val) (Synonyms: Cyclo(RGDfV); C(RGDfV))

Customer Review

Other Forms of Cyclo(Arg-Gly-Asp-D-Phe-Val):

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关抗体

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关产品

•同靶点产品:

•同靶点蛋白产品:

查看 Integrin 亚型特异性产品:

生物活性

纯度 & 产品资料

参考文献

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关抗体:

Cyclo(Arg-Gly-Asp-D-Phe-Val) 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

Keywords:

您最近查看的产品:

Request for HNMR Report

Request for HNMR Report

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z