2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. DIPPA hydrochloride

DIPPA (hydrochloride) 是一种不可逆、长效、选择性和高亲和力的 κ-opioid receptor 拮抗剂。DIPPA (hydrochloride)可用于焦虑和抗抑郁活性分子的研究。

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DIPPA hydrochloride Chemical Structure

DIPPA hydrochloride Chemical Structure

CAS No. : 155512-52-0

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规格 价格 是否有货 数量
5 mg ￥2846
In-stock
10 mg ￥4558
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

DIPPA hydrochloride 相关抗体

Top Publications Citing Use of Products

查看 Opioid Receptor 亚型特异性产品:

查看所有亚型
μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DIPPA (hydrochloride) is an irreversible, long-lasting, selective and high affinity κ-opioid receptor antagonist. DIPPA (hydrochloride) can be used for the research of anxiety and antidepressant[1][2][3][4].

IC50 & Target

κ Opioid Receptor/KOR

 

体内研究
(In Vivo)

DIPPA (2.5 and 5 mg/kg; s.c.) hydrochloride decreases the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats[2].
DIPPA (1 and 5 mg/kg; s.c.) hydrochloride high dose increases immobility in SD rats compared to the saline-treated strain control group[2].
DIPPA (5 mg/kg) hydrochloride decreases consumption in SD rats compared to the 5 mg/kg group of Wistar Kyoto rats. DIPPA hydrochloride significantly decreases burying time in both strains. DIPPA (5 mg/kg) hydrochloride decreases burying in both strains compared to the within strain control groups. DIPPA hydrochloride tends to decrease consumption in SD rats in the home cage but significantly increases feeding in the novel cage where potential anxiolytic-like effects of DIPPA hydrochloride may oppose the hypophagic effects of the compound[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 2.5 and 5 mg/kg
Administration: S.c.
Result: Decreased the latency to feed in Wistar Kyoto rats, but treatment did not alter approach latencies in SD rats.
Animal Model: Wistar Kyoto rats and SD rats (250–300 g)[2]
Dosage: 1 and 5 mg/kg
Administration: S.c.
Result: High dose increased immobility in SD rats compared to the saline-treated strain control group.
分子量

484.87

Formula

C22H24Cl3N3OS
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 24 mg/mL (49.50 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0624 mL 10.3120 mL 20.6241 mL
5 mM 0.4125 mL 2.0624 mL 4.1248 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.7%

COA (288 KB) 元素分析报告 (212 KB)

产品使用指南 (1538 KB)
参考文献

DIPPA hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0624 mL 10.3120 mL 20.6241 mL 51.5602 mL
5 mM 0.4125 mL 2.0624 mL 4.1248 mL 10.3120 mL
10 mM 0.2062 mL 1.0312 mL 2.0624 mL 5.1560 mL
15 mM 0.1375 mL 0.6875 mL 1.3749 mL 3.4373 mL
20 mM 0.1031 mL 0.5156 mL 1.0312 mL 2.5780 mL
25 mM 0.0825 mL 0.4125 mL 0.8250 mL 2.0624 mL
30 mM 0.0687 mL 0.3437 mL 0.6875 mL 1.7187 mL
40 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2890 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DIPPA155512-52-0Opioid Receptorirreversiblelong-lastingselectiveaffinityanxietyantidepressantInhibitorinhibitorinhibit

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产品名称：
DIPPA hydrochloride
目录号：
HY-101223
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