2. Apoptosis GPCR/G Protein Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Apoptosis P2Y Receptor Reactive Oxygen Species
  4. Diquafosol

Diquafosol  (Synonyms: INS365 free base)

目录号: HY-B0606A
产品使用指南

摩尔计算器

Diquafosol (INS365 free base) 是一种有效的 P2Y2 激动剂。Diquafosol 可抑制细胞凋亡 (apoptosis) 并减少 ROS 生成。Diquafosol 具有用于研究干眼症的潜力。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Diquafosol Chemical Structure

Diquafosol Chemical Structure

CAS No. : 59985-21-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Diquafosol 的其他形式现货产品:

Other Forms of Diquafosol:

Diquafosol 相关抗体

Top Publications Citing Use of Products

查看 P2Y Receptor 亚型特异性产品:

查看所有亚型
P2Y1 Receptor P2Y2 Receptor P2Y6 Receptor P2Y12 Receptor P2Y13 Receptor P2Y14 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Diquafosol (INS365 free base) is a potent P2Y2 agonist. Diquafosol nhibits apoptosis and decreases ROS generation. Diquafosol has the potential for the research of dry eye[1].

IC50 & Target[1]

P2Y2 Receptor

 

体外研究
(In Vitro)

Diquafosol (3%; 24 h) 可抑制干燥条件下 hCEC 细胞凋亡并减少 ROS 生成[1]。
Diquafosol (3%; 24 h) 可增加 hCEC 中磷酸化 Erk1/2、磷酸化 Akt 和磷酸化 p90RSK 的蛋白质表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Diquafosol 相关抗体:

Western Blot Analysis[1]

Cell Line: human corneal epithelial cells (hCECs)
Concentration: 3% (diluted at 1:100)
Incubation Time: 24 h
Result: Increased the protein expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK.
体内研究
(In Vivo)

Diquafosol (ophthalmic solution 3%; eyedrop, four times daily for 28 days) 可降低大鼠细胞内的 ROS 水平、细胞凋亡和炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks, 160-180 g Wistar female rats (dry eye model)[1]
Dosage: ophthalmic solution 3%
Administration: eyedrop, four times daily (8, 12 AM; 4, 8 PM) for 28 days
Result: Increased the expression of phospho-Erk1/2, phospho-Akt, and phospho-p90RSK, inhibits apoptosis, decreased the IL-1β, TNF-α expression.
分子量

790.31

Formula

C18H26N4O23P4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Diquafosol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diquafosol59985-21-6INS365INS 365INS-365ApoptosisP2Y ReceptorReactive Oxygen SpeciesROShCECsdry eyeapoptosisphospho-Erk1/2phospho-Aktphospho-p90RSKInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Diquafosol
目录号：
HY-B0606A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z