2. Antibody-drug Conjugate/ADC Related
  3. ADC Cytotoxin
  4. Docetaxal

Docetaxal  (Synonyms: 10-Acetyl docetaxel; PNU-101383)

目录号: HY-B0018 纯度: 99.54%
COA 产品使用指南

摩尔计算器

Docetaxal (10-Acetyl docetaxel) 是一种 Docetaxel (HY-B0011) 类似物。Docetaxel 是一微管拆卸抑制剂，具有抗有丝分裂活性。

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Docetaxal Chemical Structure

Docetaxal Chemical Structure

CAS No. : 125354-16-7

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规格 价格 是否有货 数量
5 mg ￥500
In-stock
10 mg ￥750
In-stock
25 mg ￥1400
In-stock
50 mg ￥2200
In-stock
100 mg ￥3500
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Docetaxal 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 2 篇科研文献

查看 ADC Cytotoxin 亚型特异性产品:

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Auristatin Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Docetaxal (10-Acetyl docetaxel) is an analog of Docetaxel (HY-B0011), with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A2780 IC50
< 0.002 μM
Compound: 16
Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A2780 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 25682561]
A549 IC50
< 0.002 μM
Compound: 16
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 25682561]
A549 IC50
< 0.002 μM
Compound: 16
Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human A549/CDDP cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 25682561]
HCT-8 IC50
< 0.002 μM
Compound: 16
Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human HCT8 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 25682561]
MCF7 IC50
< 0.002 μM
Compound: 16
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 25682561]
NIH3T3 IC50
< 0.002 μM
Compound: 16
Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
Antiproliferative activity against mouse NIH/3T3 cells assessed as growth inhibition after 48 hrs by sulforhodamine B assay
[PMID: 25682561]
体外研究
(In Vitro)

Docetaxal is an anticancer compound extracted from patent CN107793382A[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Docetaxal 相关抗体:
分子量

849.92

Formula

C45H55NO15
CAS 号
性状

固体

颜色

White to off-white

中文名称

紫杉醇EP杂质G (10-乙酰多西他赛)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (117.66 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1766 mL 5.8829 mL 11.7658 mL
5 mM 0.2353 mL 1.1766 mL 2.3532 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.54%

COA (301 KB) HNMR (307 KB) LCMS (88 KB)

产品使用指南 (1538 KB)
参考文献

Docetaxal 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1766 mL 5.8829 mL 11.7658 mL 29.4145 mL
5 mM 0.2353 mL 1.1766 mL 2.3532 mL 5.8829 mL
10 mM 0.1177 mL 0.5883 mL 1.1766 mL 2.9415 mL
15 mM 0.0784 mL 0.3922 mL 0.7844 mL 1.9610 mL
20 mM 0.0588 mL 0.2941 mL 0.5883 mL 1.4707 mL
25 mM 0.0471 mL 0.2353 mL 0.4706 mL 1.1766 mL
30 mM 0.0392 mL 0.1961 mL 0.3922 mL 0.9805 mL
40 mM 0.0294 mL 0.1471 mL 0.2941 mL 0.7354 mL
50 mM 0.0235 mL 0.1177 mL 0.2353 mL 0.5883 mL
60 mM 0.0196 mL 0.0980 mL 0.1961 mL 0.4902 mL
80 mM 0.0147 mL 0.0735 mL 0.1471 mL 0.3677 mL
100 mM 0.0118 mL 0.0588 mL 0.1177 mL 0.2941 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Docetaxal125354-16-710-Acetyl docetaxel PNU-101383紫杉醇EP杂质G (10-乙酰多西他赛)PNU101383PNU 101383PNU-101383ADC CytotoxinADC PayloadDocetaxelanalogmicrotubuledisassemblyantimitoticInhibitorinhibitorinhibit

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