2. PROTAC Autophagy Immunology/Inflammation Apoptosis Cell Cycle/DNA Damage
  3. PROTACs FKBP
  4. dTAGV-1-NEG TFA

dTAGV-1-NEG TFA 是一种非对映异构体，是 dTAGV-1 的异双功能阴性对照。dTAGV-1-NEG TFA 是一种 FKBP12F36V 选择性降解剂。

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dTAGV-1-NEG TFA Chemical Structure

dTAGV-1-NEG TFA Chemical Structure

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Other Forms of dTAGV-1-NEG TFA:

dTAGV-1-NEG TFA 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12F36V-selective degrader[1].

体外研究
(In Vitro)

dTAGV-1-NEG TFA (1-10 μM; 24 h) not induces the degradation of FKBP12F36V-Nluc on 293FT FKBP12F36V-Nluc or FKBP12WT-Nluc cells[1].
dTAGV-1-NEG TFA (500 nM; 24 h) dose not induce the degradation of KRASG12V protein in PATU-8902 FKBP12F36V-KRASG12V and KRAS?/? cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

dTAGV-1-NEG TFA 相关抗体:

Western Blot Analysis[1]

Cell Line: PATU-8902 FKBP12F36V-KRASG12V, KRAS−/− cells
Concentration: 50, 500 nM
Incubation Time: 24 hours
Result: Not induced the degradation of KRASG12V protein.

Cell Viability Assay[1]

Cell Line: EWS502 FKBP12F36V-GFP cells
Concentration: 1 μM
Incubation Time: 0, 2, 4, 6, 8 days
Result: Showed relative growth of cells same as the control group, higher than dTAGV-1 treated group.
分子量

1361.56

Formula

C70H91F3N6O16S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

dTAGV-1-NEG TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dTAGV-1-NEGPROTACsFKBPFK506-binding proteinvon Hippel-LindauVHLE3 ligaseheterobifunctional negative controldTAGV-1KRASG12VInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-145514B
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