2. PROTAC Apoptosis Cell Cycle/DNA Damage Autophagy Immunology/Inflammation
  3. PROTACs FKBP
  4. dTAGV-1-NEG

dTAGV-1-NEG 是一种非对映异构体，是 dTAGV-1 的异双功能阴性对照。dTAGV-1 是一种 FKBP12F36V 选择性降解剂。

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dTAGV-1-NEG Chemical Structure

dTAGV-1-NEG Chemical Structure

CAS No. : 2451573-87-6

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规格 价格 是否有货 数量
1 mg ￥4500
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Other Forms of dTAGV-1-NEG:

dTAGV-1-NEG 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

dTAGV-1-NEG is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1 is an FKBP12F36V-selective degrader[1].

体外研究
(In Vitro)

dTAGV-1-NEG (1-10 μM; 24 h) not induces the degradation of FKBP12F36V-Nluc on 293FT FKBP12F36V-Nluc or FKBP12WT-Nluc cells[1].
dTAGV-1-NEG (500 nM; 24 h) dose not induce the degradation of KRASG12V protein in PATU-8902 FKBP12F36V-KRASG12V and KRAS?/? cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

dTAGV-1-NEG 相关抗体:

Western Blot Analysis[1]

Cell Line: PATU-8902 FKBP12F36V-KRASG12V, KRAS−/− cells
Concentration: 500 nM
Incubation Time: 1-24 h
Result: Not induced the degradation of KRASG12V protein.
分子量

1247.54

Formula

C68H90N6O14S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.40%

COA (287 KB)

产品使用指南 (1538 KB)
参考文献

dTAGV-1-NEG 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dTAGV-1-NEG2451573-87-6PROTACsFKBPFK506-binding proteinvon Hippel-Lindau (VHL) E3 ligaseheterobifunctional negative controldTAGV-1KRASG12VInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-145514A
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